Motif ID: Hoxc13_Hoxd13

Z-value: 1.018




Activity profile for motif Hoxc13_Hoxd13.

activity profile for motif Hoxc13_Hoxd13


Sorted Z-values histogram for motif Hoxc13_Hoxd13

Sorted Z-values for motif Hoxc13_Hoxd13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 80 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_54945038 6.102 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr10_-_8518801 5.740 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr1_-_56978534 5.559 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_108213086 5.501 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr17_-_6477102 4.463 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_6270475 4.122 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr16_-_74411776 3.559 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr7_-_73537621 3.334 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr17_+_75178911 2.579 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr11_+_77216180 2.482 ENSMUST00000037912.5
ENSMUST00000156488.1
 Ssh2

slingshot homolog 2 (Drosophila)

chr19_-_7341848 2.431 ENSMUST00000171393.1
 Mark2
MAP/microtubule affinity-regulating kinase 2
chr17_+_75178797 2.409 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr16_+_23226014 2.175 ENSMUST00000178797.1
 St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr18_+_69346143 2.110 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr5_+_17574268 1.809 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_7319291 1.395 ENSMUST00000128319.1
 Clcn5
chloride channel 5
chrX_-_7319186 1.310 ENSMUST00000115746.1
 Clcn5
chloride channel 5
chr9_-_96719404 1.302 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38
chr3_-_142169196 1.290 ENSMUST00000098568.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr6_+_71909046 1.280 ENSMUST00000055296.8
 Polr1a
polymerase (RNA) I polypeptide A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 6.1 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.3 5.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 5.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.2 5.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.7 4.1 GO:0009405 pathogenesis(GO:0009405)
1.2 3.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 2.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.6 2.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 2.3 GO:0006275 regulation of DNA replication(GO:0006275)
0.5 2.2 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.2 2.1 GO:0042118 endothelial cell activation(GO:0042118)
0.4 1.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 1.8 GO:0003350 pulmonary myocardium development(GO:0003350)
0.3 1.3 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.2 1.3 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.2 1.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 1.1 GO:0010761 fibroblast migration(GO:0010761)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0000118 histone deacetylase complex(GO:0000118)
1.8 5.5 GO:0031088 platelet dense granule membrane(GO:0031088)
1.7 5.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 3.6 GO:0030673 axolemma(GO:0030673)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 1.8 GO:0043194 axon initial segment(GO:0043194)
0.1 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.3 0.8 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0008146 sulfotransferase activity(GO:0008146)
1.8 5.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.2 5.0 GO:0050436 microfibril binding(GO:0050436)
0.3 4.1 GO:0015643 toxic substance binding(GO:0015643)
0.4 3.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 3.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 2.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 2.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.4 2.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.5 2.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 1.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 1.3 GO:0031432 titin binding(GO:0031432)
0.1 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 1.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 5.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.5 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 4.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 2.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.3 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 0.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling