Motif ID: Nkx2-1

Z-value: 0.640


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.361.4e-01Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 2.642 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr19_+_44493472 2.383 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr4_+_89688196 1.973 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr1_+_12718496 1.759 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr5_+_128601106 1.392 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chrX_+_58030999 1.258 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr11_+_117849223 1.242 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chrX_+_58030622 1.165 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr2_-_57114970 1.155 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr14_-_47411666 1.141 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_+_71786923 1.045 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr4_-_9643638 1.003 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr14_+_75455957 0.989 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr12_+_55598917 0.968 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr2_+_121506715 0.954 ENSMUST00000028676.5
 Wdr76
WD repeat domain 76
chr11_+_117849286 0.953 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr1_+_97024681 0.899 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr2_+_121506748 0.848 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chr17_-_34627365 0.830 ENSMUST00000064953.8
ENSMUST00000170345.1
ENSMUST00000171121.2
ENSMUST00000168391.2
ENSMUST00000169067.2
 Ppt2




palmitoyl-protein thioesterase 2




chr4_-_21685782 0.797 ENSMUST00000076206.4
 Prdm13
PR domain containing 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.3 2.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 2.0 GO:0060179 male mating behavior(GO:0060179)
0.4 1.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 1.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.3 1.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.3 1.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 1.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 1.0 GO:0035878 nail development(GO:0035878)
0.3 0.8 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.3 0.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.8 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.2 0.7 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.6 GO:1904587 response to glycoprotein(GO:1904587)
0.1 0.6 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.1 0.6 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 0.5 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.5 GO:0071455 cellular response to hyperoxia(GO:0071455)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 2.2 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.5 GO:0002177 manchette(GO:0002177)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.2 2.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 1.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.0 GO:0038132 neuregulin binding(GO:0038132)
0.0 1.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.8 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0042054 histone methyltransferase activity(GO:0042054)
0.2 0.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.1 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)