Motif ID: Tbp

Z-value: 3.255


Transcription factors associated with Tbp:

Gene SymbolEntrez IDGene Name
Tbp ENSMUSG00000014767.10 Tbp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbpmm10_v2_chr17_+_15499888_15499960-0.814.7e-05Click!


Activity profile for motif Tbp.

activity profile for motif Tbp


Sorted Z-values histogram for motif Tbp

Sorted Z-values for motif Tbp



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 22.320 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_103853199 18.507 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_-_138842429 14.753 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr13_+_21717626 12.983 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr1_-_171196229 10.122 ENSMUST00000111332.1
 Pcp4l1
Purkinje cell protein 4-like 1
chr13_+_23575753 9.437 ENSMUST00000105105.1
 Hist1h3d
histone cluster 1, H3d
chr1_+_109993982 9.432 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr7_-_142899985 9.314 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr7_-_137314394 9.035 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr13_-_21783391 8.448 ENSMUST00000099704.3
 Hist1h3i
histone cluster 1, H3i
chr13_+_23581563 8.030 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_+_23752267 8.013 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr13_+_113035111 7.942 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
 Cdc20b




cell division cycle 20B




chr13_+_51846673 7.812 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr17_+_24720063 7.765 ENSMUST00000170715.1
ENSMUST00000054289.6
ENSMUST00000146867.1
 Rps2


ribosomal protein S2


chr6_-_87981482 7.652 ENSMUST00000056403.5
 H1fx
H1 histone family, member X
chr13_+_23544052 7.518 ENSMUST00000075558.2
 Hist1h3f
histone cluster 1, H3f
chr13_-_99900645 7.511 ENSMUST00000022150.6
 Cartpt
CART prepropeptide
chr13_+_23763660 7.348 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr11_+_94936224 7.233 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 77.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 31.5 GO:0006334 nucleosome assembly(GO:0006334)
1.7 22.3 GO:0042573 retinoic acid metabolic process(GO:0042573)
4.3 21.7 GO:0015671 oxygen transport(GO:0015671)
1.2 20.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
3.0 14.8 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 10.7 GO:0002227 innate immune response in mucosa(GO:0002227)
2.6 10.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
2.3 9.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.8 7.8 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.6 7.8 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 7.7 GO:0006342 chromatin silencing(GO:0006342)
2.5 7.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
1.1 7.4 GO:0016584 nucleosome positioning(GO:0016584)
1.0 7.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
2.4 7.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
2.2 6.6 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 6.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.7 6.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 6.4 GO:0033119 negative regulation of RNA splicing(GO:0033119)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 83.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.9 33.6 GO:0000786 nucleosome(GO:0000786)
0.0 30.9 GO:0070062 extracellular exosome(GO:0070062)
0.5 24.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 17.9 GO:0043209 myelin sheath(GO:0043209)
1.5 11.9 GO:0005833 hemoglobin complex(GO:0005833)
0.4 11.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 10.6 GO:0005680 anaphase-promoting complex(GO:0005680)
1.4 9.6 GO:0097452 GAIT complex(GO:0097452)
3.1 9.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
2.4 7.2 GO:0005584 collagen type I trimer(GO:0005584)
0.0 7.2 GO:0030141 secretory granule(GO:0030141)
0.0 7.2 GO:0031965 nuclear membrane(GO:0031965)
0.1 6.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 6.4 GO:0000776 kinetochore(GO:0000776)
0.1 6.2 GO:0000793 condensed chromosome(GO:0000793)
0.1 6.0 GO:0005871 kinesin complex(GO:0005871)
0.1 5.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.7 5.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.9 5.5 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 66.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 36.7 GO:0042393 histone binding(GO:0042393)
0.1 23.2 GO:0003735 structural constituent of ribosome(GO:0003735)
3.7 22.3 GO:0019841 retinol binding(GO:0019841)
4.3 21.7 GO:0005344 oxygen transporter activity(GO:0005344)
2.1 21.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
3.2 9.6 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
1.9 9.3 GO:0035240 dopamine binding(GO:0035240)
0.2 7.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 7.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 7.4 GO:0032564 dATP binding(GO:0032564)
0.5 7.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 7.1 GO:0097602 cullin family protein binding(GO:0097602)
0.2 7.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 7.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.2 6.6 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.9 6.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 6.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 6.0 GO:0003777 microtubule motor activity(GO:0003777)
0.2 5.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 14.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 14.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 12.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 12.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 9.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 7.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 6.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 6.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.3 5.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 3.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.5 PID_TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 107.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.5 24.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.3 20.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 10.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 9.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 9.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.8 9.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 9.1 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3 8.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 8.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.3 7.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 7.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 7.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.3 6.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.7 6.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 6.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.9 5.8 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 5.5 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 5.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation