Motif ID: Alx4

Z-value: 0.530


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_93642388-0.465.8e-02Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_26989974 1.715 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr10_+_97479470 1.569 ENSMUST00000105287.3
 Dcn
decorin
chr9_+_123366921 1.423 ENSMUST00000038863.7
 Lars2
leucyl-tRNA synthetase, mitochondrial
chr9_+_119063429 1.307 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr11_+_58171648 1.295 ENSMUST00000020820.1
 Mrpl22
mitochondrial ribosomal protein L22
chr10_-_77166545 1.224 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr3_+_146121655 1.189 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chrM_+_9452 1.173 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_-_37138863 1.163 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr8_-_4779513 0.997 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr2_+_20737306 0.988 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr15_+_9436028 0.932 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chrM_+_8600 0.921 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chrM_+_2743 0.905 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr6_-_136875794 0.898 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr13_-_100786402 0.892 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chrX_-_134111852 0.865 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr3_+_94372794 0.863 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr13_+_104229366 0.846 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr4_+_105789869 0.840 ENSMUST00000184254.1
 Gm12728
predicted gene 12728

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.8 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 1.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 1.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 1.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.3 GO:0051693 actin filament capping(GO:0051693)
0.1 1.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.2 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.3 1.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 1.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.3 1.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.3 0.9 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 0.9 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.9 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.9 GO:0030500 regulation of bone mineralization(GO:0030500)
0.3 0.8 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.2 0.8 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 2.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.1 1.1 GO:0016272 prefoldin complex(GO:0016272)
0.2 0.9 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 0.9 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.9 GO:0000125 PCAF complex(GO:0000125)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.7 GO:0097422 tubular endosome(GO:0097422)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 1.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.2 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 1.0 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 1.0 GO:0005179 hormone activity(GO:0005179)
0.3 0.9 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 0.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.9 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0017025 TBP-class protein binding(GO:0017025)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.6 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_P73PATHWAY p73 transcription factor network
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs