Motif ID: Nfic_Nfib

Z-value: 1.267

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.106.9e-01Click!
Nfibmm10_v2_chr4_-_82505707_82505739-0.077.8e-01Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_118052235 3.112 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr6_+_17306335 2.993 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr11_+_78324200 2.962 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr3_-_8667033 2.356 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr5_-_53707532 2.234 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr6_+_135362931 2.068 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr10_+_86302854 1.938 ENSMUST00000132307.1
 Timp3
tissue inhibitor of metalloproteinase 3
chr2_+_13573927 1.819 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr6_+_17306415 1.800 ENSMUST00000150901.1
 Cav1
caveolin 1, caveolae protein
chr14_+_31134853 1.793 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr9_+_44134562 1.692 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr10_+_57784859 1.672 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr7_+_45017953 1.655 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr7_-_116237767 1.636 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr16_+_90831113 1.624 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr11_+_61485431 1.607 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr6_+_29433248 1.466 ENSMUST00000101617.2
ENSMUST00000065090.5
 Flnc

filamin C, gamma

chr4_-_93335510 1.465 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr14_+_59625281 1.393 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr1_+_185454803 1.375 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.8 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 4.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 3.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.7 3.0 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 2.8 GO:0048747 muscle fiber development(GO:0048747)
0.2 2.6 GO:0060134 prepulse inhibition(GO:0060134)
0.6 2.4 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.3 2.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.7 2.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 2.1 GO:0060325 face morphogenesis(GO:0060325)
0.1 1.9 GO:0032060 bleb assembly(GO:0032060)
0.4 1.8 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.5 1.6 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.3 1.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.5 1.5 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 1.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.1 1.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 1.3 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.1 3.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.5 GO:0042383 sarcolemma(GO:0042383)
0.8 2.3 GO:0071953 elastic fiber(GO:0071953)
0.0 1.9 GO:0005925 focal adhesion(GO:0005925)
0.5 1.8 GO:0045098 type III intermediate filament(GO:0045098)
0.0 1.8 GO:0005911 cell-cell junction(GO:0005911)
0.1 1.6 GO:0005915 zonula adherens(GO:0005915)
0.0 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.4 GO:0043195 terminal bouton(GO:0043195)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.2 1.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.8 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.7 4.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 3.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 2.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.6 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.8 2.4 GO:0035939 microsatellite binding(GO:0035939)
0.2 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.5 1.8 GO:1990254 keratin filament binding(GO:1990254)
0.3 1.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.3 1.4 GO:0050436 microfibril binding(GO:0050436)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 1.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.3 GO:0008430 selenium binding(GO:0008430)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 3.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.4 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.2 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix