Motif ID: Nkx3-2

Z-value: 0.719


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_104409992 3.064 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr15_-_66969616 1.961 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr5_-_139130159 1.840 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_+_3332426 1.562 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr9_+_57940104 1.489 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr3_-_80802789 1.454 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr1_+_172341197 1.426 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr17_-_45686899 1.425 ENSMUST00000156254.1
 Tmem63b
transmembrane protein 63b
chr15_-_102624922 1.401 ENSMUST00000183765.1
 ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr15_-_100584075 1.390 ENSMUST00000184908.1
 POU6F1
POU domain, class 6, transcription factor 1 (Pou6f1), mRNA
chr15_-_102625061 1.383 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
 ATF7


Cyclic AMP-dependent transcription factor ATF-7


chr6_-_136171722 1.381 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr14_+_80000292 1.277 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr4_+_102421518 1.205 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_-_120747248 1.184 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr2_-_156992021 1.152 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
 Ndrg3


N-myc downstream regulated gene 3


chr2_+_120629113 1.144 ENSMUST00000150912.1
ENSMUST00000180041.1
 Stard9

START domain containing 9

chr3_-_82074639 1.123 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr9_-_21037775 1.102 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr10_-_86732409 1.087 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 2.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 1.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 1.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 1.5 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 1.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.4 1.4 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 1.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 1.3 GO:0019085 early viral transcription(GO:0019085)
0.0 1.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.2 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 1.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.1 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 1.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.2 1.0 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
0.1 1.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 0.9 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.1 0.9 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 2.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.8 GO:0042641 actomyosin(GO:0042641)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.4 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.1 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 1.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.5 1.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 1.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.5 1.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 0.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 0.8 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 0.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.8 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 2.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.6 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 0.5 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs