Motif ID: Twist1

Z-value: 1.245


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.581.2e-02Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_25610533 5.156 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr6_-_95718800 3.440 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr11_-_59290746 3.222 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr7_-_75308373 2.928 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr2_-_172940299 2.773 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr6_+_85187438 2.611 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr9_-_114844090 2.583 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr1_+_74791516 2.583 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr9_-_44342332 2.515 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr7_+_45216671 2.485 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_-_127218390 2.470 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr6_-_124813065 2.343 ENSMUST00000149610.2
 Tpi1
triosephosphate isomerase 1
chr10_-_127030813 2.268 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr7_-_127218303 2.177 ENSMUST00000106313.1
 Sept1
septin 1
chr9_+_65265173 2.148 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_+_4119525 2.110 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 2.105 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr9_+_60794468 2.095 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_+_71050160 1.726 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chr16_-_18811615 1.650 ENSMUST00000096990.3
 Cdc45
cell division cycle 45

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.2 4.6 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.0 3.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.4 3.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
1.1 3.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.2 3.0 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.9 2.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 2.8 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.5 2.6 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 2.5 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 2.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 2.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.4 GO:0048255 mRNA stabilization(GO:0048255)
0.8 2.3 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 2.3 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.4 2.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 2.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.3 2.0 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.5 1.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.5 1.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0031012 extracellular matrix(GO:0031012)
0.5 4.6 GO:0072687 meiotic spindle(GO:0072687)
1.4 4.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.6 3.4 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.0 3.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 2.9 GO:0043195 terminal bouton(GO:0043195)
0.1 2.8 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.8 2.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.4 GO:0005844 polysome(GO:0005844)
0.5 2.1 GO:0043293 apoptosome(GO:0043293)
0.5 1.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.1 1.0 GO:0097542 ciliary tip(GO:0097542)
0.2 0.9 GO:0043259 laminin-10 complex(GO:0043259)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0005525 GTP binding(GO:0005525)
1.1 4.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 3.9 GO:0003746 translation elongation factor activity(GO:0003746)
1.1 3.4 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.1 3.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.6 2.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 2.8 GO:0070700 BMP receptor binding(GO:0070700)
0.3 2.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.4 2.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 2.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 2.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.4 GO:0045182 translation regulator activity(GO:0045182)
0.2 2.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 1.5 GO:0097677 STAT family protein binding(GO:0097677)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 2.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.8 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 2.3 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 2.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 1.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation