Motif ID: Fosl2_Bach2

Z-value: 1.161

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.881.4e-06Click!
Bach2mm10_v2_chr4_+_32238950_322389640.437.3e-02Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 7.709 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr14_+_65968483 4.563 ENSMUST00000022616.6
 Clu
clusterin
chr18_+_32938955 4.425 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chrY_-_1286563 3.592 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_-_124769548 3.495 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr14_+_27622433 3.417 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr8_+_95703037 3.393 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr9_-_20728219 3.309 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr3_-_88503187 3.298 ENSMUST00000120377.1
 Lmna
lamin A
chr3_+_55461758 3.296 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr2_-_45110241 3.227 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr2_-_36105271 3.172 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr2_+_156475803 2.973 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_156475844 2.807 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_+_54949388 2.800 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr2_-_151632471 2.741 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr14_+_101840602 2.711 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr13_-_54611332 2.682 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr6_+_124996681 2.629 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr6_+_17463927 2.609 ENSMUST00000115442.1
 Met
met proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 6.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.2 5.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 4.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.8 4.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.7 4.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 4.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 3.9 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.3 3.7 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.5 3.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 3.4 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 3.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 3.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.8 3.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.5 3.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.6 3.0 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.4 2.8 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.3 2.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 2.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 2.5 GO:0071625 vocalization behavior(GO:0071625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0001650 fibrillar center(GO:0001650)
0.1 7.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 6.2 GO:0055037 recycling endosome(GO:0055037)
0.8 5.9 GO:0005638 lamin filament(GO:0005638)
0.5 5.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.7 4.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 4.4 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.0 4.1 GO:0016324 apical plasma membrane(GO:0016324)
0.2 3.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 3.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.3 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.7 3.0 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 3.0 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 2.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3 2.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 7.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 5.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.4 5.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 5.1 GO:0008017 microtubule binding(GO:0008017)
0.2 4.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 4.8 GO:0042805 actinin binding(GO:0042805)
0.2 4.6 GO:0051787 misfolded protein binding(GO:0051787)
0.4 4.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 4.2 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.9 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.9 3.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 3.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 3.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 3.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 3.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 2.8 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 5.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 5.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 4.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.2 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 2.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.7 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 1.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.2 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 5.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 5.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 4.5 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 2.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 2.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 2.4 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events