Motif ID: Fosl2_Bach2
Z-value: 1.161
Transcription factors associated with Fosl2_Bach2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bach2 | ENSMUSG00000040270.10 | Bach2 |
| Fosl2 | ENSMUSG00000029135.9 | Fosl2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Fosl2 | mm10_v2_chr5_+_32136458_32136505 | 0.88 | 1.4e-06 | Click! |
| Bach2 | mm10_v2_chr4_+_32238950_32238964 | 0.43 | 7.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 5.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.8 | 3.2 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.8 | 2.4 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.8 | 4.6 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.7 | 4.4 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.6 | 3.0 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.5 | 3.2 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.5 | 3.6 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.4 | 2.8 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.4 | 1.1 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.4 | 1.9 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.4 | 1.8 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.4 | 1.1 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.3 | 2.8 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.3 | 2.1 | GO:0046103 | ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103) |
| 0.3 | 1.4 | GO:0035624 | receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) |
| 0.3 | 0.3 | GO:0030862 | positive regulation of polarized epithelial cell differentiation(GO:0030862) |
| 0.3 | 3.7 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.3 | 1.7 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.3 | 1.0 | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
| 0.3 | 0.9 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.3 | 1.2 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.3 | 4.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.3 | 2.7 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.3 | 0.8 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.3 | 1.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 2.2 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.3 | 3.4 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.3 | 1.8 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.2 | 2.4 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.2 | 0.7 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 0.2 | 0.6 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
| 0.2 | 1.7 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
| 0.2 | 0.6 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.2 | 7.7 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.2 | 1.8 | GO:0030049 | muscle filament sliding(GO:0030049) |
| 0.2 | 2.4 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.2 | 2.4 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.2 | 0.7 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 0.6 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.2 | 0.8 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.2 | 0.8 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.2 | 0.8 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.1 | 0.4 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.1 | 3.9 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.1 | 0.9 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.9 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.1 | 0.6 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.1 | 0.6 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 0.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 0.2 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) |
| 0.1 | 0.5 | GO:0060715 | syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715) |
| 0.1 | 1.9 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.1 | 1.1 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 0.3 | GO:0051462 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of cortisol secretion(GO:0051464) |
| 0.1 | 0.7 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 1.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 1.0 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.1 | 0.3 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.1 | 0.7 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 0.4 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.1 | 0.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 3.3 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.1 | 0.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 1.5 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.1 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 2.5 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 1.1 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.1 | 6.5 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.1 | 0.2 | GO:1901911 | diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.1 | 1.7 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.3 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.1 | 0.4 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.1 | 0.5 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.1 | 0.4 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 0.2 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.1 | 0.5 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 3.4 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 0.2 | GO:0035937 | estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864) |
| 0.1 | 0.2 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.1 | 0.4 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 0.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 0.3 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.1 | 2.3 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 4.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.5 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.9 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.0 | 0.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.0 | 0.7 | GO:0006622 | protein targeting to lysosome(GO:0006622) regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543) |
| 0.0 | 0.6 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.9 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.9 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.0 | 0.3 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.0 | 2.0 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway(GO:0042058) |
| 0.0 | 0.5 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.9 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.0 | 0.1 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.0 | 1.8 | GO:0045806 | negative regulation of endocytosis(GO:0045806) |
| 0.0 | 0.4 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.5 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.0 | 1.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.8 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.2 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.0 | 0.2 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.3 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.0 | 0.4 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 1.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 1.9 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 0.1 | GO:0001996 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) regulation of systemic arterial blood pressure by norepinephrine-epinephrine(GO:0001993) positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) |
| 0.0 | 0.2 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.2 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.2 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.0 | 0.6 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.0 | 0.7 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.0 | 0.6 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 1.8 | GO:0030641 | regulation of cellular pH(GO:0030641) |
| 0.0 | 0.5 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.2 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.4 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.0 | 0.2 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.0 | 0.8 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 2.1 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.4 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.0 | 0.8 | GO:0090630 | activation of GTPase activity(GO:0090630) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.9 | GO:0005638 | lamin filament(GO:0005638) |
| 0.7 | 3.0 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.7 | 4.6 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.5 | 2.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.5 | 1.9 | GO:0031673 | H zone(GO:0031673) |
| 0.5 | 5.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.4 | 3.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.4 | 1.1 | GO:0044753 | amphisome(GO:0044753) |
| 0.4 | 1.1 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.3 | 1.2 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.3 | 1.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 1.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.3 | 2.1 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.2 | 3.9 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 1.3 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.2 | 0.6 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.2 | 0.8 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.2 | 1.4 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 1.8 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.4 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.1 | 3.0 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 0.7 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 2.0 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 7.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 3.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 0.8 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 0.9 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 2.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 3.7 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 1.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.7 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 0.8 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 9.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 0.8 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.8 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.6 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 4.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 6.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 1.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.9 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.1 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 4.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 4.4 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 0.3 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 1.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 3.3 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 1.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.2 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.2 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 0.5 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 1.9 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 1.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.3 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 0.5 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.5 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.5 | 1.4 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.5 | 2.8 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.4 | 5.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.4 | 2.8 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.4 | 3.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.4 | 4.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.3 | 2.4 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.3 | 3.8 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.3 | 1.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.2 | 1.1 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 7.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.2 | 0.6 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.2 | 0.4 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.2 | 5.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 4.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 2.1 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.2 | 4.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 2.7 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.2 | 0.6 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.2 | 2.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 0.5 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.2 | 3.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 0.8 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 1.2 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 1.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.1 | 3.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 4.8 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 0.8 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 3.0 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 1.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 1.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 2.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.6 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 0.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.8 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.4 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.1 | 4.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 0.5 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 0.5 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.1 | 2.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.7 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 2.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 0.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.3 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 2.0 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.4 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.1 | 0.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 1.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 1.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.2 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.1 | 0.2 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 1.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.7 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.2 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.0 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 3.4 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.8 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.3 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.3 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 1.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 2.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 2.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 9.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.2 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 0.1 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.0 | 1.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.2 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.0 | 2.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 5.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 1.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.9 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.1 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.0 | 1.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.2 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 1.5 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.9 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.0 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.0 | 0.1 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 3.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.0 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.2 | 1.2 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.2 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.1 | 2.7 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 7.0 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 4.1 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 1.7 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 4.5 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 1.1 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.1 | 1.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.0 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.6 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 4.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 0.5 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 1.1 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.2 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.2 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 2.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.8 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.4 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.9 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.7 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 1.3 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.4 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.4 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.8 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.1 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 2.8 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.2 | 2.2 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 2.4 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.2 | 2.8 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.2 | 2.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 5.8 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 4.5 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 5.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.3 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 1.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.8 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 2.4 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 0.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.8 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.0 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 0.5 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 0.9 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 0.7 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 1.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.6 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 1.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.9 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 2.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.6 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 1.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.4 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 2.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.4 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.1 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.3 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
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