Motif ID: Dmc1

Z-value: 0.672


Transcription factors associated with Dmc1:

Gene SymbolEntrez IDGene Name
Dmc1 ENSMUSG00000022429.10 Dmc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmc1mm10_v2_chr15_-_79605084_796051140.727.0e-04Click!


Activity profile for motif Dmc1.

activity profile for motif Dmc1


Sorted Z-values histogram for motif Dmc1

Sorted Z-values for motif Dmc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dmc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_14562171 1.805 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr4_+_128058962 1.327 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr1_-_38821215 1.275 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr16_-_43979050 1.259 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr17_+_55445375 1.130 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr14_+_75955003 1.092 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr2_-_104257400 1.001 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr18_+_23415400 0.992 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr8_-_69774884 0.954 ENSMUST00000137573.1
ENSMUST00000149782.1
 Zfp866
Gm20422
zinc finger protein 866
predicted gene 20422
chr10_+_69534208 0.911 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial





chr5_+_37185897 0.884 ENSMUST00000094840.3
 Gm1043
predicted gene 1043
chr16_+_72663143 0.848 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr2_+_130405256 0.843 ENSMUST00000110281.1
ENSMUST00000028898.3
 1700020A23Rik

RIKEN cDNA 1700020A23 gene

chr8_+_66386292 0.817 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_+_107437908 0.770 ENSMUST00000094541.2
 Btbd8
BTB (POZ) domain containing 8
chr10_+_69534039 0.731 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr6_+_135198034 0.729 ENSMUST00000130612.1
 8430419L09Rik
RIKEN cDNA 8430419L09 gene
chr17_+_85613432 0.728 ENSMUST00000176081.1
 Six3
sine oculis-related homeobox 3
chr1_-_134955847 0.726 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr15_-_43869993 0.719 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.3 GO:0007416 synapse assembly(GO:0007416)
0.0 1.2 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 1.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 1.0 GO:0006710 androgen catabolic process(GO:0006710)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.9 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 0.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.8 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 0.7 GO:0097402 neuroblast migration(GO:0097402)
0.2 0.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.7 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.6 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.6 GO:0008340 determination of adult lifespan(GO:0008340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0042641 actomyosin(GO:0042641)
0.1 1.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.2 GO:0031672 A band(GO:0031672)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.6 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.6 GO:0005605 basal lamina(GO:0005605)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0032590 dendrite membrane(GO:0032590)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.0 1.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.8 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 0.6 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.5 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.5 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 0.5 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.1 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 0.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis