Motif ID: Egr4

Z-value: 0.796


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 4.518 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_25505618 2.704 ENSMUST00000025755.4
 Dmrt1
doublesex and mab-3 related transcription factor 1
chr13_+_48261427 2.599 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr2_-_102186322 2.270 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr12_+_17690793 1.735 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr5_-_149051604 1.566 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1
chr17_-_31658729 1.460 ENSMUST00000166526.1
ENSMUST00000014684.4
 U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr3_+_135438722 1.416 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr18_+_35829798 1.302 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr9_+_65630552 1.221 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chr8_-_92355764 1.147 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr11_-_87987528 1.144 ENSMUST00000020775.2
 Dynll2
dynein light chain LC8-type 2
chr16_+_93883895 1.097 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr17_-_23677432 1.065 ENSMUST00000167059.1
ENSMUST00000024698.8
 Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr10_+_19591949 1.060 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr6_-_85451248 0.992 ENSMUST00000113770.1
ENSMUST00000032080.2
 Pradc1

protease-associated domain containing 1

chr16_-_36071515 0.980 ENSMUST00000004057.7
 Fam162a
family with sequence similarity 162, member A
chr4_+_128883549 0.955 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr16_+_64851991 0.943 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr16_+_36071624 0.931 ENSMUST00000164916.1
ENSMUST00000163352.1
 Ccdc58

coiled-coil domain containing 58


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 2.7 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.6 2.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 2.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 2.1 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 2.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.4 1.9 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.5 1.6 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 1.2 GO:0070613 regulation of protein processing(GO:0070613)
0.4 1.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 1.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 1.1 GO:0030238 male sex determination(GO:0030238)
0.0 1.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 1.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.0 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 0.8 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 2.3 GO:0001726 ruffle(GO:0001726)
0.1 2.1 GO:0030914 STAGA complex(GO:0030914)
0.2 1.5 GO:0089701 U2AF(GO:0089701)
0.4 1.1 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 4.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 2.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.9 GO:0032183 SUMO binding(GO:0032183)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 1.6 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 1.5 GO:0050733 RS domain binding(GO:0050733)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 1.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 1.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.7 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.7 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 0.7 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.5 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.1 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling