Motif ID: Sox8

Z-value: 0.470


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.571.4e-02Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_65512678 2.649 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr3_+_102010138 2.073 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr3_-_8667033 1.602 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr4_-_58553553 1.022 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr7_-_126800354 0.956 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr11_-_26591729 0.946 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr19_+_24875679 0.916 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr10_-_128180265 0.855 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr13_-_66227573 0.810 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr7_-_126800036 0.778 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr6_-_119467210 0.678 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr13_-_81710937 0.678 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr1_+_109993982 0.632 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr13_-_19395728 0.607 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr11_+_69991633 0.591 ENSMUST00000108592.1
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr18_-_62741387 0.587 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr11_+_113659283 0.562 ENSMUST00000137878.1
 Cog1
component of oligomeric golgi complex 1
chr1_+_109983737 0.465 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2
chr15_-_97020322 0.414 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr11_-_43747963 0.414 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chrX_-_72918284 0.358 ENSMUST00000152200.1
 Cetn2
centrin 2
chr4_-_129578535 0.325 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr13_-_66852017 0.323 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr18_+_80046854 0.315 ENSMUST00000070219.7
 Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr11_-_118909487 0.289 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr14_-_49783327 0.288 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr11_+_69991061 0.274 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr8_+_34807287 0.268 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chrX_-_23285532 0.236 ENSMUST00000115319.2
 Klhl13
kelch-like 13
chr18_-_84951477 0.217 ENSMUST00000025547.2
 Timm21
tranlocase of inner mitochondrial membrane 21
chr2_+_69789647 0.193 ENSMUST00000112266.1
 Phospho2
phosphatase, orphan 2
chr8_-_33747724 0.188 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chr4_-_134245579 0.177 ENSMUST00000030644.7
 Zfp593
zinc finger protein 593
chr2_+_18677002 0.172 ENSMUST00000028071.6
 Bmi1
Bmi1 polycomb ring finger oncogene
chr4_+_154142363 0.164 ENSMUST00000030895.5
 Wrap73
WD repeat containing, antisense to Trp73
chr1_+_36307745 0.154 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
 Arid5a





AT rich interactive domain 5A (MRF1-like)





chr2_+_69789621 0.122 ENSMUST00000151298.1
ENSMUST00000028494.2
 Phospho2

phosphatase, orphan 2

chr11_-_110095974 0.120 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr11_-_69758630 0.114 ENSMUST00000058470.9
 Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr7_-_42578588 0.113 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr11_-_110095937 0.094 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr10_+_82378593 0.074 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chr15_-_103215285 0.064 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr19_-_41263931 0.042 ENSMUST00000025989.8
 Tm9sf3
transmembrane 9 superfamily member 3
chr9_-_32541589 0.032 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr16_-_29541483 0.018 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr9_-_60838200 0.014 ENSMUST00000063858.7
 Gm9869
predicted gene 9869

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.3 0.9 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.3 1.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.6 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.9 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.2 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.2 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.7 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150) mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.4 GO:0071942 XPC complex(GO:0071942)
0.0 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0035939 microsatellite binding(GO:0035939)
0.3 1.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.3 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane