Motif ID: Hoxc9

Z-value: 0.688


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_102977032-0.262.9e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Showing 1 to 20 of 61 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_35423582 2.348 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr18_+_65582239 1.770 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chr10_+_4710119 1.769 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr2_-_26516620 1.621 ENSMUST00000132820.1
 Notch1
notch 1
chrX_+_56609751 1.512 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr6_-_99044414 1.369 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chr18_+_65582281 1.217 ENSMUST00000183319.1
 Zfp532
zinc finger protein 532
chr4_+_100776664 1.110 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chrX_-_143933089 0.967 ENSMUST00000087313.3
 Dcx
doublecortin
chr7_-_116038734 0.854 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr2_+_4300462 0.834 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr2_-_84650714 0.793 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr18_+_65582390 0.763 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr2_-_84650760 0.698 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr1_+_66321708 0.692 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr6_-_119388671 0.667 ENSMUST00000169744.1
 Adipor2
adiponectin receptor 2
chr2_-_84650490 0.666 ENSMUST00000066177.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650676 0.663 ENSMUST00000067232.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chrX_-_141474034 0.631 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr3_+_67892189 0.626 ENSMUST00000063263.3
 Iqcj
IQ motif containing J

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.3 2.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.0 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.4 1.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.5 1.6 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.1 1.4 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.4 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.3 2.0 GO:0044308 axonal spine(GO:0044308)
0.3 1.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.3 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.2 GO:0071914 prominosome(GO:0071914)
0.0 0.2 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.6 1.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.6 GO:0005112 Notch binding(GO:0005112)
0.3 1.3 GO:0055100 adiponectin binding(GO:0055100)
0.1 1.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction