Motif ID: Olig2_Olig3

Z-value: 0.777

Transcription factors associated with Olig2_Olig3:

Gene SymbolEntrez IDGene Name
Olig2 ENSMUSG00000039830.8 Olig2
Olig3 ENSMUSG00000045591.5 Olig3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Olig2mm10_v2_chr16_+_91225550_91225579-0.465.3e-02Click!
Olig3mm10_v2_chr10_+_19356558_19356565-0.116.7e-01Click!


Activity profile for motif Olig2_Olig3.

activity profile for motif Olig2_Olig3


Sorted Z-values histogram for motif Olig2_Olig3

Sorted Z-values for motif Olig2_Olig3



Network of associatons between targets according to the STRING database.



First level regulatory network of Olig2_Olig3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 4.863 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr3_-_154330543 3.368 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr19_-_53589067 3.253 ENSMUST00000095978.3
 Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr1_-_186117251 3.080 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr1_+_12692430 2.624 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr16_-_44558864 2.616 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr9_-_119825456 2.563 ENSMUST00000070617.7
 Scn11a
sodium channel, voltage-gated, type XI, alpha
chr16_-_44558879 2.532 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr2_-_105399286 2.323 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr3_+_125404292 2.184 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr17_-_62606679 2.110 ENSMUST00000163332.1
 Efna5
ephrin A5
chr10_+_53596936 2.081 ENSMUST00000020004.6
 Asf1a
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr3_+_125404072 2.080 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr16_+_16213318 1.966 ENSMUST00000162150.1
ENSMUST00000161342.1
ENSMUST00000039408.2
 Pkp2


plakophilin 2


chr11_-_69920892 1.960 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr9_+_66946057 1.892 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr4_+_15957923 1.747 ENSMUST00000029879.8
ENSMUST00000149069.1
 Nbn

nibrin

chr11_+_32276400 1.727 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr15_-_55548164 1.698 ENSMUST00000165356.1
 Mrpl13
mitochondrial ribosomal protein L13
chr1_+_51987139 1.656 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.5 3.1 GO:0098734 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734)
0.1 3.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 2.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 2.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.4 2.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 2.5 GO:0021884 forebrain neuron development(GO:0021884)
0.2 2.1 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.7 2.0 GO:0002159 desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496)
0.1 2.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.7 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.4 1.6 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 1.5 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.3 1.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 1.5 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 1.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0044295 axonal growth cone(GO:0044295)
0.6 3.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.7 GO:0030057 desmosome(GO:0030057)
0.9 2.6 GO:0044299 C-fiber(GO:0044299)
0.2 2.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.7 GO:0030870 Mre11 complex(GO:0030870)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.2 1.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.3 1.0 GO:0034457 Mpp10 complex(GO:0034457)
0.2 1.0 GO:0070552 BRISC complex(GO:0070552)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 3.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.5 2.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 2.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 2.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 2.1 GO:0045499 chemorepellent activity(GO:0045499)
0.2 2.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 1.8 GO:0008494 translation activator activity(GO:0008494)
0.3 1.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 1.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.5 1.5 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 1.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 1.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 1.1 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 2.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.7 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID_ATM_PATHWAY ATM pathway
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.5 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 2.4 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 2.2 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 2.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.0 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.2 0.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.8 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis