Motif ID: Hoxb8_Pdx1

Z-value: 0.649

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_39846958 1.686 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr5_+_106609098 1.545 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr17_-_53539411 0.839 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr1_-_33907721 0.774 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr14_+_11227511 0.770 ENSMUST00000080237.3
 Rpl21-ps4
ribosomal protein L21, pseudogene 4
chr9_+_40269273 0.750 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr1_+_10993452 0.744 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_+_40269202 0.734 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr15_+_21111452 0.715 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_+_96115249 0.675 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr7_+_44384098 0.625 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chrX_+_38600626 0.606 ENSMUST00000000365.2
 Mcts1
malignant T cell amplified sequence 1
chr2_-_131043088 0.603 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr9_+_99243421 0.598 ENSMUST00000093795.3
 Cep70
centrosomal protein 70
chr4_-_41723129 0.582 ENSMUST00000171641.1
ENSMUST00000030158.4
 Dctn3

dynactin 3

chr8_+_118283719 0.576 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr13_+_93304066 0.557 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr17_+_55892184 0.540 ENSMUST00000054780.8
 Zfp959
zinc finger protein 959
chr6_-_52012476 0.530 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr11_+_17051818 0.498 ENSMUST00000058159.5
 Cnrip1
cannabinoid receptor interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 1.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.0 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 1.0 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 0.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.8 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.0 0.6 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.4 GO:0071677 positive regulation of mononuclear cell migration(GO:0071677)
0.0 0.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.4 GO:0034198 cellular response to amino acid starvation(GO:0034198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.1 0.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.8 GO:0045298 tubulin complex(GO:0045298)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.6 GO:0000800 lateral element(GO:0000800)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.4 GO:0097386 glial cell projection(GO:0097386)
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 1.0 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 0.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.3 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins