Motif ID: E2f4
Z-value: 2.472
Transcription factors associated with E2f4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f4 | ENSMUSG00000014859.8 | E2f4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f4 | mm10_v2_chr8_+_105297663_105297742 | 0.89 | 6.7e-07 | Click! |
Top targets:
Showing 1 to 20 of 168 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 100 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.9 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 3.7 | 14.8 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.5 | 14.2 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.3 | 11.4 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.3 | 8.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 8.1 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 1.4 | 7.0 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.3 | 6.6 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 2.1 | 6.4 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
| 2.1 | 6.4 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.3 | 6.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 5.9 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 5.8 | GO:0007051 | spindle organization(GO:0007051) |
| 0.4 | 5.1 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.1 | 4.9 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 1.5 | 4.5 | GO:0072076 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.7 | 4.4 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.6 | 4.4 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 1.4 | 4.3 | GO:0070782 | phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.1 | 4.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 61 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.1 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.1 | 13.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 1.9 | 11.4 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 1.5 | 10.2 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 8.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.7 | 7.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 7.0 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 6.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.9 | 6.4 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.1 | 6.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 6.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 5.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 5.8 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 5.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.0 | 4.9 | GO:0031523 | Myb complex(GO:0031523) |
| 0.4 | 4.7 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 4.7 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 4.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 4.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 4.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 70 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 17.9 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 2.1 | 14.8 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.3 | 12.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.4 | 7.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 7.0 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.2 | 6.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.7 | 6.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 6.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 5.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 5.1 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.6 | 4.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 4.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.5 | 4.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.5 | 4.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 4.3 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.4 | 4.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 4.1 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.1 | 3.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 1.1 | 3.3 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) single guanine insertion binding(GO:0032142) |
| 0.3 | 3.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 14.8 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.3 | 12.0 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 9.1 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.3 | 8.1 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 7.0 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 6.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.2 | 5.8 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.3 | 4.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 4.5 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.1 | 2.8 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 2.1 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.6 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 1.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.2 | 1.4 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 1.3 | ST_GAQ_PATHWAY | G alpha q Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 38 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.9 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.1 | 14.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 12.9 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.5 | 12.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.6 | 11.0 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 8.0 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.3 | 7.2 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.2 | 7.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.7 | 6.6 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 6.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 6.4 | REACTOME_SIGNALING_BY_FGFR3_MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 6.2 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 4.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.3 | 4.1 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 4.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 3.0 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 2.3 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 2.0 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.9 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 1.8 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
