Motif ID: Yy1_Yy2

Z-value: 4.461

Transcription factors associated with Yy1_Yy2:

Gene SymbolEntrez IDGene Name
Yy1 ENSMUSG00000021264.11 Yy1
Yy2 ENSMUSG00000091736.2 Yy2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Yy2mm10_v2_chrX_-_157598642_157598655-0.542.2e-02Click!
Yy1mm10_v2_chr12_+_108792946_1087929880.145.8e-01Click!


Activity profile for motif Yy1_Yy2.

activity profile for motif Yy1_Yy2


Sorted Z-values histogram for motif Yy1_Yy2

Sorted Z-values for motif Yy1_Yy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Yy1_Yy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_25610533 17.883 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr16_-_22163299 13.525 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr18_+_20665250 12.631 ENSMUST00000075312.3
 Ttr
transthyretin
chr11_+_94741782 12.110 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr17_-_23829095 11.197 ENSMUST00000069579.5
 Tceb2
transcription elongation factor B (SIII), polypeptide 2
chr16_+_30065333 10.550 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr3_-_90213577 10.307 ENSMUST00000170122.2
 Rps27
ribosomal protein S27
chr18_-_13972617 9.061 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr7_-_78783026 8.875 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr8_-_107263248 8.740 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr1_+_129273344 8.679 ENSMUST00000073527.6
ENSMUST00000040311.7
 Thsd7b

thrombospondin, type I, domain containing 7B

chr19_-_50030735 8.647 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr9_+_107399858 8.639 ENSMUST00000085092.5
ENSMUST00000164988.2
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr13_+_21811737 8.554 ENSMUST00000104941.2
 Hist1h4m
histone cluster 1, H4m
chr5_+_127241807 8.140 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr14_-_54617993 7.981 ENSMUST00000022803.4
 Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr10_-_128549102 7.966 ENSMUST00000176906.1
 Rpl41
ribosomal protein L41
chr11_+_75732869 7.791 ENSMUST00000067664.3
 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_+_146121655 7.777 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr10_-_128549125 7.734 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
 Rpl41


ribosomal protein L41



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 890 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 84.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 63.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.8 44.6 GO:0032543 mitochondrial translation(GO:0032543)
1.0 43.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.7 38.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 29.7 GO:0006412 translation(GO:0006412)
1.4 23.0 GO:0043248 proteasome assembly(GO:0043248)
0.8 21.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
2.9 20.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.8 17.7 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.2 17.7 GO:0006413 translational initiation(GO:0006413)
1.0 17.5 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
1.6 17.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 16.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
2.0 16.1 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.5 15.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 14.9 GO:0006270 DNA replication initiation(GO:0006270)
0.2 14.8 GO:0042254 ribosome biogenesis(GO:0042254)
3.6 14.5 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
1.3 14.4 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 118.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.4 78.8 GO:0000788 nuclear nucleosome(GO:0000788)
1.5 78.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.2 69.9 GO:0044391 ribosomal subunit(GO:0044391)
0.2 69.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 62.3 GO:0005615 extracellular space(GO:0005615)
1.2 59.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.3 42.5 GO:0015935 small ribosomal subunit(GO:0015935)
1.0 37.1 GO:0000786 nucleosome(GO:0000786)
1.3 30.2 GO:0005839 proteasome core complex(GO:0005839)
0.2 22.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 20.6 GO:0005730 nucleolus(GO:0005730)
0.3 20.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 19.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 19.2 GO:0005581 collagen trimer(GO:0005581)
1.3 17.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.6 17.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 16.7 GO:1903561 extracellular vesicle(GO:1903561)
3.1 15.6 GO:0032133 chromosome passenger complex(GO:0032133)
1.0 14.5 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 535 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 271.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 65.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 33.0 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.6 32.7 GO:0003743 translation initiation factor activity(GO:0003743)
1.1 30.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.3 29.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 25.1 GO:0003723 RNA binding(GO:0003723)
0.7 20.2 GO:0008432 JUN kinase binding(GO:0008432)
0.4 19.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.9 17.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.5 16.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.7 15.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.7 15.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.0 15.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.7 15.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 14.2 GO:0035326 enhancer binding(GO:0035326)
0.2 14.2 GO:0008083 growth factor activity(GO:0008083)
0.8 13.0 GO:0003680 AT DNA binding(GO:0003680)
1.4 12.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.8 12.7 GO:1990226 histone methyltransferase binding(GO:1990226)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 36.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 36.1 PID_AURORA_B_PATHWAY Aurora B signaling
1.0 29.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 25.2 PID_E2F_PATHWAY E2F transcription factor network
0.7 24.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 21.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 17.7 NABA_COLLAGENS Genes encoding collagen proteins
0.3 15.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 14.6 PID_PLK1_PATHWAY PLK1 signaling events
0.4 13.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 13.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 12.0 PID_ATR_PATHWAY ATR signaling pathway
0.3 12.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.6 10.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.4 10.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 10.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 10.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 10.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 10.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.7 9.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 200.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.1 111.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.2 84.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.4 75.2 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.5 37.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 31.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 29.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 29.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.4 25.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.6 24.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 22.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 21.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.7 17.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 16.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 16.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.8 15.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.1 14.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.4 14.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 14.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4 14.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC