Motif ID: Hic1

Z-value: 2.088


Transcription factors associated with Hic1:

Gene SymbolEntrez IDGene Name
Hic1 ENSMUSG00000043099.4 Hic1



Activity profile for motif Hic1.

activity profile for motif Hic1


Sorted Z-values histogram for motif Hic1

Sorted Z-values for motif Hic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 8.697 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr2_-_157079212 6.639 ENSMUST00000069098.6
 Soga1
suppressor of glucose, autophagy associated 1
chr2_-_36105271 6.366 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr8_-_84800344 6.176 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr13_+_109903089 5.381 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr9_+_45430293 5.329 ENSMUST00000034592.8
 Dscaml1
Down syndrome cell adhesion molecule like 1
chr6_-_32588192 5.235 ENSMUST00000115096.2
 Plxna4
plexin A4
chr17_-_32284715 5.022 ENSMUST00000127893.1
 Brd4
bromodomain containing 4
chr5_+_144768536 4.885 ENSMUST00000128550.1
 Trrap
transformation/transcription domain-associated protein
chr7_+_96210107 4.880 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr3_-_148989316 4.809 ENSMUST00000098518.2
 Lphn2
latrophilin 2
chr5_-_122050102 4.554 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr11_-_6065538 4.508 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr17_-_32788284 4.406 ENSMUST00000159086.2
 Zfp871
zinc finger protein 871
chr14_-_30353468 4.358 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr5_-_146585239 4.091 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr4_-_123664725 4.081 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr9_+_26733845 3.947 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr4_-_46991842 3.888 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr4_-_45084538 3.726 ENSMUST00000052236.6
 Fbxo10
F-box protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 467 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.9 15.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 7.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 7.1 GO:0030032 lamellipodium assembly(GO:0030032)
2.3 6.9 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.2 6.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 6.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 6.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 6.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.5 5.9 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.6 5.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 5.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.3 5.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.7 5.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
1.2 4.9 GO:0032289 central nervous system myelin formation(GO:0032289)
0.6 4.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 4.6 GO:0043968 histone H2A acetylation(GO:0043968)
1.1 4.5 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.4 4.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.2 4.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 38.0 GO:0016021 integral component of membrane(GO:0016021)
0.1 29.1 GO:0060076 excitatory synapse(GO:0060076)
0.1 22.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 12.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 12.0 GO:0034702 ion channel complex(GO:0034702)
0.3 11.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 8.6 GO:0051233 spindle midzone(GO:0051233)
0.2 6.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 6.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.9 5.8 GO:0098855 HCN channel complex(GO:0098855)
0.1 5.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 5.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.3 5.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 5.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 4.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 4.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 4.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 4.3 GO:0097513 myosin II filament(GO:0097513)
0.3 4.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 299 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.3 GO:0005096 GTPase activator activity(GO:0005096)
0.4 10.5 GO:0043274 phospholipase binding(GO:0043274)
1.3 7.7 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.9 7.1 GO:0046790 virion binding(GO:0046790)
0.0 7.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 6.8 GO:0003924 GTPase activity(GO:0003924)
0.3 6.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 6.6 GO:0008017 microtubule binding(GO:0008017)
1.4 5.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.4 5.8 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.2 5.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 5.5 GO:0050811 GABA receptor binding(GO:0050811)
0.3 5.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.7 5.2 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.5 5.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.4 5.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 5.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 4.9 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 8.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 7.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.4 6.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 6.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 6.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 6.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 5.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 5.0 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 5.0 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.7 PID_MYC_PATHWAY C-MYC pathway
0.1 4.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.8 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.2 3.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.6 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 10.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.3 9.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 8.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 8.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 7.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 6.1 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.2 5.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 5.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 4.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 4.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 4.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 4.0 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.3 3.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.8 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways