Motif ID: Mafa

Z-value: 1.741


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.753.2e-04Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_98032983 11.671 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr16_+_91269759 10.924 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_+_54835959 10.758 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr9_-_98033181 10.196 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr14_+_119138415 8.234 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr10_+_58813359 6.461 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr1_-_169747634 6.238 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr16_-_17576631 5.994 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr4_+_102254993 5.765 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_136260873 4.861 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr4_+_102254739 3.931 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr16_-_74411776 3.921 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr1_-_38836090 3.851 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr12_+_3365108 3.303 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr4_+_21931291 2.985 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr16_-_74411292 2.914 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chrX_-_73869804 2.791 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr10_-_84440591 2.710 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr1_-_121327776 2.644 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr9_-_48835932 2.527 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 10.9 GO:0048663 neuron fate commitment(GO:0048663)
0.7 9.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 9.2 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.4 8.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
2.3 6.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 6.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 4.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 4.3 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.8 4.0 GO:0034436 glycoprotein transport(GO:0034436)
0.0 3.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 3.3 GO:0072384 organelle transport along microtubule(GO:0072384)
0.2 3.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 2.7 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.5 2.5 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.2 2.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.6 2.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 2.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 2.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.5 1.9 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 10.9 GO:0005667 transcription factor complex(GO:0005667)
0.4 9.7 GO:0000930 gamma-tubulin complex(GO:0000930)
1.1 9.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 6.8 GO:0030673 axolemma(GO:0030673)
0.3 4.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.3 3.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 3.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 2.7 GO:0044294 dendritic growth cone(GO:0044294)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.8 GO:0043679 axon terminus(GO:0043679)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0005883 neurofilament(GO:0005883)
0.0 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 9.9 GO:0008134 transcription factor binding(GO:0008134)
0.3 9.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
2.1 8.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.8 6.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 6.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 6.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
1.3 4.0 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 3.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 3.2 GO:0019894 kinesin binding(GO:0019894)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 2.8 GO:0033691 sialic acid binding(GO:0033691)
0.0 2.7 GO:0002039 p53 binding(GO:0002039)
0.3 2.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.4 2.2 GO:0070728 leucine binding(GO:0070728)
0.1 2.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 2.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 2.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 8.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 6.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 6.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 3.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 1.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors