Motif ID: Pax4

Z-value: 0.466


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_32696005 1.418 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr15_-_79164477 1.153 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr12_-_90738438 1.094 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chrX_+_9199865 1.079 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr5_-_103100054 1.041 ENSMUST00000112848.1
 Mapk10
mitogen-activated protein kinase 10
chr4_-_88033328 0.916 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_136284658 0.894 ENSMUST00000144217.1
 Zfp46
zinc finger protein 46
chr13_+_109632760 0.820 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr4_+_136284708 0.768 ENSMUST00000130223.1
 Zfp46
zinc finger protein 46
chr12_+_71048338 0.748 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr13_-_101768154 0.705 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_+_158667119 0.651 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_+_62574523 0.635 ENSMUST00000018651.7
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr12_+_33314277 0.580 ENSMUST00000133549.1
 Atxn7l1
ataxin 7-like 1
chr6_+_136518820 0.569 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr12_-_98577940 0.566 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr7_+_7171330 0.559 ENSMUST00000051435.7
 Zfp418
zinc finger protein 418
chr2_+_158666690 0.553 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr8_-_84773381 0.539 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_+_143518671 0.535 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_116288944 0.495 ENSMUST00000086483.3
 Ccdc60
coiled-coil domain containing 60
chr2_-_168741898 0.482 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chrX_+_73192222 0.478 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chr2_+_73271925 0.461 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chrX_+_142227923 0.455 ENSMUST00000042329.5
 Nxt2
nuclear transport factor 2-like export factor 2
chr6_+_47877204 0.453 ENSMUST00000061890.7
 Zfp282
zinc finger protein 282
chr9_-_48835932 0.424 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chrX_-_73097017 0.415 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr5_-_116591811 0.394 ENSMUST00000076124.5
 Srrm4
serine/arginine repetitive matrix 4
chrX_+_142228177 0.382 ENSMUST00000112914.1
 Nxt2
nuclear transport factor 2-like export factor 2
chr2_-_114175274 0.379 ENSMUST00000102543.4
 Aqr
aquarius
chr13_-_66851513 0.362 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr10_+_107271827 0.361 ENSMUST00000020057.8
ENSMUST00000105280.3
 Lin7a

lin-7 homolog A (C. elegans)

chr4_+_150281573 0.361 ENSMUST00000105682.2
 Rere
arginine glutamic acid dipeptide (RE) repeats
chr7_-_45366714 0.353 ENSMUST00000107779.1
 Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr15_-_88978958 0.341 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr10_+_90071095 0.333 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr16_+_15637844 0.328 ENSMUST00000023352.8
 Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr5_-_121502980 0.324 ENSMUST00000079368.3
 Adam1b
a disintegrin and metallopeptidase domain 1b
chr2_-_131328982 0.314 ENSMUST00000110194.1
 Rnf24
ring finger protein 24
chr2_-_168741752 0.314 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr2_-_33086366 0.288 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr17_+_26941420 0.281 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr18_+_53862087 0.275 ENSMUST00000069597.6
 Csnk1g3
casein kinase 1, gamma 3
chr13_-_66852017 0.270 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chrX_-_8206475 0.268 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
 Porcn



porcupine homolog (Drosophila)



chr1_-_88008520 0.259 ENSMUST00000040783.4
 Usp40
ubiquitin specific peptidase 40
chr13_+_75089826 0.257 ENSMUST00000022075.4
 Pcsk1
proprotein convertase subtilisin/kexin type 1
chr4_+_136357423 0.250 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr9_-_101198999 0.246 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr4_+_150087365 0.226 ENSMUST00000094451.3
 Gpr157
G protein-coupled receptor 157
chr10_+_127421208 0.222 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr5_-_116288978 0.216 ENSMUST00000050178.6
 Ccdc60
coiled-coil domain containing 60
chr14_-_12823031 0.211 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
 Cadps



Ca2+-dependent secretion activator



chr15_+_80977765 0.193 ENSMUST00000139517.1
ENSMUST00000042506.8
ENSMUST00000137255.1
 Sgsm3


small G protein signaling modulator 3


chr13_+_23738804 0.185 ENSMUST00000040914.1
 Hist1h1c
histone cluster 1, H1c
chr10_+_119992916 0.178 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr5_+_124552845 0.150 ENSMUST00000071057.7
 Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr8_+_8689666 0.149 ENSMUST00000179702.1
 B930078G14Rik
RIKEN cDNA B930078G14 gene
chr13_-_23430826 0.144 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr4_+_146610961 0.122 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr2_+_22895583 0.111 ENSMUST00000152170.1
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr10_+_127421124 0.105 ENSMUST00000170336.1
 R3hdm2
R3H domain containing 2
chr12_-_84218835 0.105 ENSMUST00000046266.6
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr15_-_59374149 0.072 ENSMUST00000022976.4
 E430025E21Rik
RIKEN cDNA E430025E21 gene
chr10_-_67548944 0.066 ENSMUST00000075686.4
 Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr4_+_125066672 0.047 ENSMUST00000052183.6
 Snip1
Smad nuclear interacting protein 1
chr9_-_103222063 0.045 ENSMUST00000170904.1
 Trf
transferrin
chr19_-_32712287 0.043 ENSMUST00000070210.4
 Atad1
ATPase family, AAA domain containing 1
chr2_-_125506385 0.041 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr8_-_4217261 0.026 ENSMUST00000168386.2
 BC068157
cDNA sequence BC068157
chr2_-_114654943 0.011 ENSMUST00000028640.7
ENSMUST00000102542.3
 Dph6

diphthamine biosynthesis 6

chrX_+_143518576 0.005 ENSMUST00000033640.7
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr17_+_69383024 0.003 ENSMUST00000112674.1
 Zbtb14
zinc finger and BTB domain containing 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 1.2 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 1.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.2 1.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.4 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.1 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.8 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 0.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.3 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.0 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.6 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.0 GO:1903011 negative regulation of bone development(GO:1903011)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.9 GO:0000800 lateral element(GO:0000800)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair