Motif ID: Pax4

Z-value: 0.466


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_32696005 1.418 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr15_-_79164477 1.153 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr12_-_90738438 1.094 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chrX_+_9199865 1.079 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr5_-_103100054 1.041 ENSMUST00000112848.1
 Mapk10
mitogen-activated protein kinase 10
chr4_-_88033328 0.916 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_136284658 0.894 ENSMUST00000144217.1
 Zfp46
zinc finger protein 46
chr13_+_109632760 0.820 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr4_+_136284708 0.768 ENSMUST00000130223.1
 Zfp46
zinc finger protein 46
chr12_+_71048338 0.748 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr13_-_101768154 0.705 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_+_158667119 0.651 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_+_62574523 0.635 ENSMUST00000018651.7
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr12_+_33314277 0.580 ENSMUST00000133549.1
 Atxn7l1
ataxin 7-like 1
chr6_+_136518820 0.569 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr12_-_98577940 0.566 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr7_+_7171330 0.559 ENSMUST00000051435.7
 Zfp418
zinc finger protein 418
chr2_+_158666690 0.553 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr8_-_84773381 0.539 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_+_143518671 0.535 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 1.2 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 1.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.2 1.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.8 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.6 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.4 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.4 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.1 0.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.3 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0000800 lateral element(GO:0000800)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 1.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.3 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation