Motif ID: Chd1_Pml

Z-value: 4.018

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pmlmm10_v2_chr9_-_58249702_582497910.302.3e-01Click!
Chd1mm10_v2_chr17_+_15704963_157049940.262.9e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66286224 24.222 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr8_-_84800024 18.530 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr8_-_84800344 16.382 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chrX_+_69360294 14.617 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr11_-_6065737 14.551 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr15_+_83779975 14.477 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr9_-_98033181 14.345 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr16_-_67620880 13.870 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr1_-_56972437 13.355 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr15_+_83779999 12.629 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr14_-_102982630 12.592 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr11_-_6065538 12.545 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr5_+_88886809 11.997 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr1_-_56971762 11.923 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr16_-_67620805 11.814 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr10_-_43174521 11.668 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr4_-_123664725 11.399 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr4_-_46991842 11.059 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_+_155775333 10.885 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr6_+_99692679 10.491 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 983 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 72.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.9 43.2 GO:0060081 membrane hyperpolarization(GO:0060081)
1.6 42.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
2.2 38.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
5.6 33.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
9.2 27.5 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
1.7 26.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.8 25.3 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
1.6 24.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.5 23.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.5 22.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.2 22.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.8 21.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
2.0 19.7 GO:0010459 negative regulation of heart rate(GO:0010459)
1.9 19.1 GO:0046959 habituation(GO:0046959)
1.6 18.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 18.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.5 18.1 GO:0061512 protein localization to cilium(GO:0061512)
0.4 17.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.4 16.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 329 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 155.0 GO:0099572 postsynaptic specialization(GO:0099572)
0.0 131.2 GO:0016021 integral component of membrane(GO:0016021)
1.5 76.5 GO:0048786 presynaptic active zone(GO:0048786)
0.3 73.6 GO:0000139 Golgi membrane(GO:0000139)
1.7 68.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 57.0 GO:0005905 clathrin-coated pit(GO:0005905)
1.6 45.7 GO:0033268 node of Ranvier(GO:0033268)
1.0 45.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 40.0 GO:0045211 postsynaptic membrane(GO:0045211)
5.7 34.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.9 30.0 GO:0051233 spindle midzone(GO:0051233)
0.2 28.8 GO:0005769 early endosome(GO:0005769)
0.6 27.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 26.8 GO:0030139 endocytic vesicle(GO:0030139)
1.0 25.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 25.3 GO:0043195 terminal bouton(GO:0043195)
0.5 24.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 24.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.8 23.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 22.4 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 538 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 98.6 GO:0005096 GTPase activator activity(GO:0005096)
0.2 78.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.0 56.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.5 44.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 41.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.7 35.3 GO:0030507 spectrin binding(GO:0030507)
0.2 35.3 GO:0008017 microtubule binding(GO:0008017)
1.1 29.1 GO:0043274 phospholipase binding(GO:0043274)
1.0 26.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 26.2 GO:0016247 channel regulator activity(GO:0016247)
0.3 23.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
3.1 22.0 GO:0099609 microtubule lateral binding(GO:0099609)
1.9 21.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 20.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
3.2 19.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.7 18.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.2 18.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
1.0 17.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
4.4 17.7 GO:0038025 reelin receptor activity(GO:0038025)
0.4 17.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 68.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.9 51.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
2.2 37.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.4 33.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 29.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.3 23.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 21.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 20.4 PID_SHP2_PATHWAY SHP2 signaling
0.3 19.2 PID_LKB1_PATHWAY LKB1 signaling events
0.8 18.7 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.6 14.5 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.6 13.4 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.5 11.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.5 11.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 10.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1 9.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.7 9.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.5 8.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 8.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.8 8.5 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 69.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.6 39.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.0 37.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 29.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 27.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.1 26.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.8 23.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.9 22.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
1.7 22.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.7 21.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.3 20.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 18.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.9 18.0 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.6 17.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.3 17.1 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.4 16.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
1.1 16.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.5 16.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
2.0 16.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.8 16.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling