Motif ID: Atf3

Z-value: 0.798


Transcription factors associated with Atf3:

Gene SymbolEntrez IDGene Name
Atf3 ENSMUSG00000026628.8 Atf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf3mm10_v2_chr1_-_191183244_1911833400.617.8e-03Click!


Activity profile for motif Atf3.

activity profile for motif Atf3


Sorted Z-values histogram for motif Atf3

Sorted Z-values for motif Atf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_122475397 1.679 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr10_+_4710119 1.453 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr6_-_23248264 1.138 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_84068766 1.137 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr15_-_78544345 1.060 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr7_-_137314394 0.952 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr4_-_97584605 0.857 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr11_-_84069179 0.856 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chrX_-_60893430 0.822 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr4_-_97584612 0.804 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_117133953 0.802 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_+_100494044 0.761 ENSMUST00000153287.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr13_-_23761223 0.726 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr12_-_10900296 0.708 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr7_-_30973399 0.706 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr1_-_71653162 0.694 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr7_-_38271310 0.684 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr1_+_74791516 0.671 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr1_+_52008210 0.668 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr19_-_40271506 0.665 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 513 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.8 GO:0034508 centromere complex assembly(GO:0034508)
0.4 1.7 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.4 1.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 1.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.5 1.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 1.4 GO:0007530 sex determination(GO:0007530)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 1.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 1.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.9 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.9 GO:0015684 ferrous iron transport(GO:0015684)
0.1 0.9 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.8 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1 0.8 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.0 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 1.8 GO:0000776 kinetochore(GO:0000776)
0.2 1.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 1.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0038201 TOR complex(GO:0038201)
0.0 1.1 GO:0005657 replication fork(GO:0005657)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.0 GO:0005840 ribosome(GO:0005840)
0.0 0.9 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.2 0.7 GO:0070557 PCNA-p21 complex(GO:0070557)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 1.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 1.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.5 1.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 1.3 GO:0019843 rRNA binding(GO:0019843)
0.1 1.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.2 GO:0005112 Notch binding(GO:0005112)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.0 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.7 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 0.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.7 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 1.6 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 0.9 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)