Motif ID: Hmx2

Z-value: 0.380


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.292.4e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_73237891 0.518 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr5_-_53707532 0.480 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr5_+_15516489 0.457 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr9_+_35423582 0.417 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr3_+_94372794 0.417 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr12_+_117843873 0.404 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr18_+_50051702 0.399 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr14_-_48667508 0.323 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr10_-_37138863 0.281 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr18_-_34579072 0.278 ENSMUST00000079287.5
 Nme5
NME/NM23 family member 5
chr10_+_37139558 0.278 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr15_+_85510812 0.256 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr18_-_88894322 0.255 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr4_-_62470868 0.252 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr6_+_29694204 0.247 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr6_+_71282280 0.243 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr11_-_100822525 0.230 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chrX_+_56786527 0.225 ENSMUST00000144600.1
 Fhl1
four and a half LIM domains 1
chr1_+_109993982 0.197 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr18_+_4993795 0.192 ENSMUST00000153016.1
 Svil
supervillin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.5 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 0.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.4 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.3 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.2 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0070269 pyroptosis(GO:0070269)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0070279 vitamin B6 binding(GO:0070279)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport