ISMARA results: Spdef

Motif ID: Spdef

Z-value: 0.429

Transcription factors associated with Spdef:

Gene Symbol	Entrez ID	Gene Name
Spdef	ENSMUSG00000024215.7	Spdef

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Spdef	mm10_v2_chr17_-_27728889_27728956	-0.52	2.8e-02	Click!

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_-_90243073	1.018	ENSMUST00000107369.1	Creb3l4	cAMP responsive element binding protein 3-like 4
chr13_+_12395362	0.730	ENSMUST00000059270.8	Heatr1	HEAT repeat containing 1
chr7_+_127876796	0.562	ENSMUST00000131000.1	Zfp646	zinc finger protein 646
chr9_+_65908967	0.540	ENSMUST00000034949.3 ENSMUST00000154589.1	Csnk1g1	casein kinase 1, gamma 1
chr2_-_26445175	0.532	ENSMUST00000114082.2 ENSMUST00000091252.4	Sec16a	SEC16 homolog A (S. cerevisiae)
chr8_+_109778554	0.473	ENSMUST00000093157.6	Ap1g1	adaptor protein complex AP-1, gamma 1 subunit
chr8_+_109778863	0.455	ENSMUST00000034171.8	Ap1g1	adaptor protein complex AP-1, gamma 1 subunit
chr15_-_89170688	0.452	ENSMUST00000060808.9	Plxnb2	plexin B2
chr13_-_19619820	0.438	ENSMUST00000002885.6	Epdr1	ependymin related protein 1 (zebrafish)
chr11_+_60777525	0.433	ENSMUST00000056907.6 ENSMUST00000102667.3	Smcr8	Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
chr9_+_30427329	0.424	ENSMUST00000164099.1	Snx19	sorting nexin 19
chr17_+_88626569	0.424	ENSMUST00000150023.1	Ston1	stonin 1
chr16_-_56712825	0.421	ENSMUST00000136394.1	Tfg	Trk-fused gene
chr11_+_83299005	0.410	ENSMUST00000176944.1	Ap2b1	adaptor-related protein complex 2, beta 1 subunit
chr1_+_61638819	0.396	ENSMUST00000138768.1 ENSMUST00000075374.3	Pard3b	par-3 partitioning defective 3 homolog B (C. elegans)
chr12_-_102878406	0.395	ENSMUST00000045652.6	Btbd7	BTB (POZ) domain containing 7
chr13_-_60177357	0.382	ENSMUST00000065086.4	Gas1	growth arrest specific 1
chr3_-_32365608	0.379	ENSMUST00000168566.1	Zmat3	zinc finger matrin type 3
chr11_+_83302817	0.374	ENSMUST00000142680.1	Ap2b1	adaptor-related protein complex 2, beta 1 subunit
chr17_-_84466186	0.373	ENSMUST00000047524.8	Thada	thyroid adenoma associated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 99 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.3	0.9	GO:0043323	positive regulation of natural killer cell degranulation(GO:0043323)
0.2	0.7	GO:0019085	early viral transcription(GO:0019085)
0.1	0.7	GO:0090070	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0	0.7	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.6	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.6	GO:0097152	mesenchymal cell apoptotic process(GO:0097152)
0.0	0.6	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968)
0.0	0.5	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.5	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.1	0.4	GO:0030200	heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1	0.4	GO:0036438	maintenance of lens transparency(GO:0036438)
0.1	0.4	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.0	0.4	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.4	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.4	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.4	GO:0042473	outer ear morphogenesis(GO:0042473)
0.0	0.4	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471)
0.0	0.4	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1	0.3	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 43 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	1.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.7	GO:0032040	small-subunit processome(GO:0032040)
0.1	0.4	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.4	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.4	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.4	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0	0.4	GO:0030904	retromer complex(GO:0030904)
0.0	0.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	0.3	GO:0008623	CHRAC(GO:0008623)
0.1	0.3	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.3	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0	0.3	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.3	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.3	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.1	0.2	GO:0000801	central element(GO:0000801)
0.1	0.2	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.2	GO:1990415	Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0	0.2	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.2	GO:0005672	transcription factor TFIIA complex(GO:0005672)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 61 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.9	GO:0008186	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1	0.8	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0	0.8	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.8	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	0.6	GO:0016300	tRNA (uracil) methyltransferase activity(GO:0016300)
0.0	0.5	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	0.4	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.4	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.1	0.4	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.4	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.4	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.4	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.1	0.3	GO:0016501	prostacyclin receptor activity(GO:0016501)
0.1	0.3	GO:0045131	pre-mRNA branch point binding(GO:0045131)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Total log-likelihood	Term	Description
0.5	PID_WNT_CANONICAL_PATHWAY	Canonical Wnt signaling pathway
0.5	PID_PS1_PATHWAY	Presenilin action in Notch and Wnt signaling
0.4	PID_IL27_PATHWAY	IL27-mediated signaling events
0.4	PID_ALK1_PATHWAY	ALK1 signaling events
0.3	PID_IL5_PATHWAY	IL5-mediated signaling events
0.3	PID_HEDGEHOG_2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	PID_WNT_SIGNALING_PATHWAY	Wnt signaling network
0.3	PID_ARF_3PATHWAY	Arf1 pathway
0.2	PID_S1P_S1P4_PATHWAY	S1P4 pathway
0.2	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	EGF receptor (ErbB1) signaling pathway
0.1	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 19 of 19 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0	0.6	REACTOME_MRNA_SPLICING_MINOR_PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.0	0.5	REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.4	REACTOME_SIGNALING_BY_NODAL	Genes involved in Signaling by NODAL
0.0	0.4	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.4	REACTOME_HS_GAG_DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.4	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.4	REACTOME_SIGNALING_BY_ROBO_RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.3	REACTOME_COPI_MEDIATED_TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.3	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.3	REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.3	REACTOME_LYSOSOME_VESICLE_BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.2	REACTOME_IL_7_SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.2	REACTOME_GAP_JUNCTION_DEGRADATION	Genes involved in Gap junction degradation
0.1	0.1	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.1	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME_REGULATION_OF_IFNG_SIGNALING	Genes involved in Regulation of IFNG signaling