Motif ID: Foxa2_Foxa1

Z-value: 1.404

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148045891_1480459480.331.8e-01Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.331.9e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5390387 6.889 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr17_-_70851710 6.510 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr14_-_48662740 6.191 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr4_-_58499398 5.038 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr17_+_29090969 4.472 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_+_73237891 4.408 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr13_-_60177357 4.154 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_-_82885148 3.908 ENSMUST00000048430.3
 Cer1
cerberus 1 homolog (Xenopus laevis)
chr12_-_56535047 3.651 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr1_+_12718496 3.362 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr6_+_15185203 3.275 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr6_-_3494587 2.998 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr2_+_14873656 2.685 ENSMUST00000114718.1
ENSMUST00000114719.1
 Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr18_-_62756275 2.665 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr18_-_84086379 2.426 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr10_-_128180265 2.386 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_172940299 2.369 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr18_-_60501983 2.357 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr1_-_138619687 2.353 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr4_-_55532453 2.318 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.6 6.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.5 6.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 5.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.5 5.1 GO:0060539 diaphragm development(GO:0060539)
1.3 5.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.6 4.8 GO:0021759 globus pallidus development(GO:0021759)
0.6 4.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 4.2 GO:0042473 outer ear morphogenesis(GO:0042473)
1.3 3.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 3.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.3 3.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 3.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 3.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 3.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 3.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 3.0 GO:0007098 centrosome cycle(GO:0007098)
0.4 2.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.9 2.7 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 2.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 6.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 5.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 4.8 GO:0005667 transcription factor complex(GO:0005667)
1.5 4.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.3 GO:0030426 growth cone(GO:0030426)
0.1 4.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 3.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.1 3.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 3.1 GO:0042555 MCM complex(GO:0042555)
0.1 2.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 2.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.2 GO:0005604 basement membrane(GO:0005604)
0.3 2.1 GO:0033269 internode region of axon(GO:0033269)
0.0 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 1.4 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 7.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.3 6.5 GO:0070410 co-SMAD binding(GO:0070410)
0.4 5.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.5 4.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.3 3.9 GO:0016015 morphogen activity(GO:0016015)
0.1 3.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 3.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 3.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 2.7 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 2.4 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.4 GO:0005521 lamin binding(GO:0005521)
0.5 2.3 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 2.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.1 1.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 6.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 4.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 4.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.5 4.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.1 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 2.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 2.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 6.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 5.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 5.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 4.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 3.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 3.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 3.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 2.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 2.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 1.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation