Motif ID: Tfap2d

Z-value: 0.752


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_19103043-0.503.4e-02Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_105637350 1.517 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr4_-_106464167 1.274 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr10_-_127534540 1.237 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr4_+_152008803 1.225 ENSMUST00000097773.3
 Klhl21
kelch-like 21
chr4_+_46450892 1.139 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr5_-_24527276 1.106 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr15_-_75747922 1.065 ENSMUST00000062002.4
 Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr7_+_65862029 1.060 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr8_-_105637403 1.057 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr2_+_119742306 1.050 ENSMUST00000028758.7
 Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr4_+_129513581 0.990 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr18_+_82910863 0.967 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr9_-_119578981 0.957 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr17_-_85688252 0.892 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr11_+_120949053 0.868 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr1_+_92831614 0.864 ENSMUST00000045970.6
 Gpc1
glypican 1
chr4_+_114406717 0.858 ENSMUST00000094894.3
 Trabd2b
TraB domain containing 2B
chr2_+_26586607 0.851 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr4_-_57143437 0.833 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr19_+_18670780 0.806 ENSMUST00000025632.9
 2410127L17Rik
RIKEN cDNA 2410127L17 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.3 1.3 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 1.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 1.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.3 1.1 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 1.1 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.1 1.1 GO:0043486 histone exchange(GO:0043486)
0.1 1.1 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.3 1.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 1.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 0.9 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2 0.9 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.1 0.9 GO:0018158 protein oxidation(GO:0018158)
0.1 0.9 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.1 0.9 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.8 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 0.8 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 1.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 1.3 GO:0005827 polar microtubule(GO:0005827)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.9 GO:0001940 male pronucleus(GO:0001940)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 0.6 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.6 GO:0043197 dendritic spine(GO:0043197)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.4 GO:0033061 DNA recombinase mediator complex(GO:0033061)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.4 1.3 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.0 1.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 1.0 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 1.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.0 GO:0005112 Notch binding(GO:0005112)
0.3 0.9 GO:0070052 collagen V binding(GO:0070052)
0.1 0.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 0.6 GO:0034618 arginine binding(GO:0034618)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.0 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS