Motif ID: Rara

Z-value: 0.855


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98927785_989278180.465.3e-02Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Showing 1 to 20 of 63 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_48045144 2.811 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_46991842 2.669 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr12_+_87026564 1.765 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr4_-_141599835 1.561 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr17_-_56133817 1.481 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_+_114131229 1.393 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr3_-_54915867 1.277 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr14_-_30353468 1.111 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_59567348 1.076 ENSMUST00000124402.1
 Fgf13
fibroblast growth factor 13
chr4_+_32238950 0.980 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr14_-_16575456 0.969 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr5_+_135806859 0.942 ENSMUST00000126232.1
 Srrm3
serine/arginine repetitive matrix 3
chr4_+_150853919 0.766 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr6_+_30723541 0.741 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr14_+_76488436 0.714 ENSMUST00000101618.2
 Tsc22d1
TSC22 domain family, member 1
chr10_+_4611971 0.706 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr2_-_34754364 0.703 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
 Gapvd1


GTPase activating protein and VPS9 domains 1


chr6_+_115601907 0.702 ENSMUST00000000449.7
 Mkrn2
makorin, ring finger protein, 2
chr2_+_120977017 0.664 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr3_-_36475688 0.615 ENSMUST00000029266.8
 Anxa5
annexin A5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.8 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 2.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 1.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 1.1 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.2 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 0.8 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 0.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.7 GO:0010883 regulation of lipid storage(GO:0010883)
0.2 0.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.2 0.6 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 0.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 0.6 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 0.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 1.7 GO:0014704 intercalated disc(GO:0014704)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 2.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.3 GO:0022839 ion gated channel activity(GO:0022839)
0.1 1.6 GO:0031005 filamin binding(GO:0031005)
0.1 1.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 1.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 0.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.2 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint