Motif ID: Ppara

Z-value: 2.347


Transcription factors associated with Ppara:

Gene SymbolEntrez IDGene Name
Ppara ENSMUSG00000022383.7 Ppara



Activity profile for motif Ppara.

activity profile for motif Ppara


Sorted Z-values histogram for motif Ppara

Sorted Z-values for motif Ppara



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppara

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 11.886 ENSMUST00000168589.1
 Sla
src-like adaptor
chr5_+_117781017 7.941 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr6_+_90550789 7.259 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr5_+_35056813 7.153 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr15_+_80091320 7.124 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr11_-_6065538 6.878 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr1_-_162478004 6.752 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr7_+_91090728 6.532 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr8_+_124793013 6.497 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr11_+_67586520 6.468 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr8_+_124793061 6.325 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr17_-_35909626 6.004 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr2_+_170731807 5.907 ENSMUST00000029075.4
 Dok5
docking protein 5
chr10_+_123264076 5.831 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr4_-_46991842 5.824 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_+_67586675 5.760 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr17_-_35910032 5.428 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr17_+_5492558 5.422 ENSMUST00000089185.4
 Zdhhc14
zinc finger, DHHC domain containing 14
chr16_-_44139630 5.412 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr15_+_100761741 5.395 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 305 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 13.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.5 12.2 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2 12.2 GO:0051453 regulation of intracellular pH(GO:0051453)
0.3 12.0 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.1 11.9 GO:0030041 actin filament polymerization(GO:0030041)
3.8 11.4 GO:0071929 alpha-tubulin acetylation(GO:0071929)
1.2 11.2 GO:0071420 cellular response to histamine(GO:0071420)
0.4 10.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 10.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 9.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.7 8.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
2.0 8.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
2.6 7.9 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.9 7.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.4 7.3 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
2.3 6.9 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.2 6.9 GO:0018345 protein palmitoylation(GO:0018345)
1.7 6.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.5 6.5 GO:0045161 neuronal ion channel clustering(GO:0045161)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.8 GO:0031594 neuromuscular junction(GO:0031594)
0.1 21.6 GO:0001726 ruffle(GO:0001726)
0.2 19.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 13.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 12.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.8 11.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 10.5 GO:0030427 site of polarized growth(GO:0030427)
0.0 10.5 GO:0045202 synapse(GO:0045202)
0.4 10.2 GO:0031430 M band(GO:0031430)
1.1 9.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.1 9.8 GO:0097427 microtubule bundle(GO:0097427)
0.0 9.8 GO:0005635 nuclear envelope(GO:0005635)
0.5 9.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 8.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 8.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 8.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.7 7.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 7.9 GO:0031252 cell leading edge(GO:0031252)
2.4 7.3 GO:0072534 perineuronal net(GO:0072534)
0.2 7.1 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.7 GO:0003779 actin binding(GO:0003779)
1.0 18.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 17.1 GO:0005158 insulin receptor binding(GO:0005158)
0.3 15.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 14.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.9 11.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 10.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 9.8 GO:0030507 spectrin binding(GO:0030507)
0.1 9.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 8.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 8.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 8.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
2.6 7.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.7 7.9 GO:0097109 neuroligin family protein binding(GO:0097109)
2.4 7.3 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.6 7.2 GO:0050897 cobalt ion binding(GO:0050897)
0.2 6.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 6.9 GO:0016247 channel regulator activity(GO:0016247)
2.3 6.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.6 6.4 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 11.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.2 9.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.4 8.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 7.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 5.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 4.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 3.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 3.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 3.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 2.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 2.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 2.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 2.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 18.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.5 14.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.7 11.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 9.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 8.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 8.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 7.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 6.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 5.5 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 4.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 3.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 3.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.5 3.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 3.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 3.5 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 3.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 3.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors