Motif ID: Atf6

Z-value: 1.231


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_170867784-0.184.8e-01Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_-_1245685 3.847 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr16_-_23988852 3.439 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr3_+_123267445 3.213 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr12_+_82616885 2.666 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr5_+_134986191 2.484 ENSMUST00000094245.2
 Cldn3
claudin 3
chr5_-_89883321 2.215 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chrX_+_41401128 2.168 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrY_-_1245753 2.119 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr6_-_126740151 1.945 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr8_+_125995102 1.869 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr5_+_35056813 1.787 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr6_-_101377897 1.774 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr5_-_136170634 1.670 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr10_+_29211637 1.594 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene
chr17_+_46297917 1.562 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr8_-_70487314 1.549 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr6_-_8778439 1.508 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
 Ica1


islet cell autoantigen 1


chr6_-_8778106 1.448 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1


chr6_+_77242644 1.434 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 1.412 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.7 5.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 3.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.3 3.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.1 3.4 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 3.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 3.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 3.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 3.0 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.3 2.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 2.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 2.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 2.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.8 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 1.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.3 1.6 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.4 GO:0060416 response to growth hormone(GO:0060416)
0.4 1.3 GO:0010360 negative regulation of anion channel activity(GO:0010360)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.7 GO:0031594 neuromuscular junction(GO:0031594)
0.3 4.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 4.4 GO:0030426 growth cone(GO:0030426)
0.2 3.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 3.4 GO:0043034 costamere(GO:0043034)
0.0 3.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.2 GO:0005657 replication fork(GO:0005657)
0.0 2.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.1 GO:0000421 autophagosome membrane(GO:0000421)
0.5 1.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 1.9 GO:0031201 SNARE complex(GO:0031201)
0.2 1.5 GO:0005827 polar microtubule(GO:0005827)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.0 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 3.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 3.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 3.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 2.8 GO:0000149 SNARE binding(GO:0000149)
0.2 2.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 2.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 1.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 1.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.5 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.2 1.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.4 GO:0008565 protein transporter activity(GO:0008565)
0.3 1.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 1.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 1.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 1.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 3.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 2.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.1 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 1.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules