Motif ID: Irf5_Irf6

Z-value: 0.599

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 69 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_57072024 1.158 ENSMUST00000169879.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr17_+_23679363 0.868 ENSMUST00000024699.2
 Cldn6
claudin 6
chr19_+_5568002 0.866 ENSMUST00000096318.3
 Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr11_+_88999376 0.820 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chrX_-_95444789 0.772 ENSMUST00000084535.5
 Amer1
APC membrane recruitment 1
chr11_+_72689997 0.754 ENSMUST00000155998.1
 Ankfy1
ankyrin repeat and FYVE domain containing 1
chr16_-_35939082 0.746 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr6_-_39118211 0.600 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr17_-_6782775 0.522 ENSMUST00000064234.6
 Ezr
ezrin
chr9_+_95954744 0.519 ENSMUST00000034981.7
 Xrn1
5'-3' exoribonuclease 1
chr6_-_13608011 0.437 ENSMUST00000031554.2
 Tmem168
transmembrane protein 168
chr7_-_126396715 0.372 ENSMUST00000075671.4
 Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr16_+_35938972 0.372 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr4_-_40239779 0.334 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_-_7295394 0.329 ENSMUST00000025921.8
 Mark2
MAP/microtubule affinity-regulating kinase 2
chr9_+_45042425 0.324 ENSMUST00000034600.4
 Mpzl2
myelin protein zero-like 2
chr9_-_123851855 0.286 ENSMUST00000184082.1
ENSMUST00000167595.2
 Fyco1

FYVE and coiled-coil domain containing 1

chr9_-_14381242 0.265 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr12_-_31950170 0.263 ENSMUST00000176520.1
 Hbp1
high mobility group box transcription factor 1
chr2_-_69586021 0.246 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
 Lrp2


low density lipoprotein receptor-related protein 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.8 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.8 GO:0032439 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.0 0.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.7 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 0.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 0.5 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.1 0.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.4 GO:0009597 detection of virus(GO:0009597)
0.1 0.3 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.3 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.2 GO:0034239 regulation of macrophage fusion(GO:0034239)
0.0 0.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 0.2 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0046654 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.2 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 0.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 0.5 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.9 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.8 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 0.2 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins