Motif ID: Mef2b

Z-value: 0.778


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.371.3e-01Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_142899985 2.765 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr6_-_23248264 2.711 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_103843154 2.192 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr7_-_144738478 1.656 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr2_-_94264713 1.474 ENSMUST00000129661.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr5_-_116422858 1.204 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr2_-_94264745 1.202 ENSMUST00000134563.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr2_-_172043466 1.190 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr7_-_100514800 1.045 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr12_-_111672290 1.019 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr7_-_144738520 0.946 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel

chrY_-_1286563 0.902 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr8_+_31089471 0.861 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr18_+_50030977 0.848 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr9_-_110654161 0.841 ENSMUST00000133191.1
ENSMUST00000167320.1
 Nbeal2

neurobeachin-like 2

chr19_-_34879452 0.840 ENSMUST00000036584.5
 Pank1
pantothenate kinase 1
chr1_-_172329261 0.819 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr17_-_58991343 0.789 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr17_+_34039437 0.783 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
 Col11a2



collagen, type XI, alpha 2



chr13_-_23698454 0.749 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.8 GO:0042414 epinephrine metabolic process(GO:0042414)
0.5 2.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 2.6 GO:0015705 iodide transport(GO:0015705)
0.4 2.2 GO:0015671 oxygen transport(GO:0015671)
0.3 1.4 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.2 1.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.3 0.9 GO:0042908 xenobiotic transport(GO:0042908)
0.3 0.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.9 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.3 0.8 GO:0070889 platelet alpha granule organization(GO:0070889)
0.3 0.8 GO:0060023 soft palate development(GO:0060023)
0.2 0.8 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.1 0.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.8 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 0.7 GO:0051866 general adaptation syndrome(GO:0051866)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0034707 chloride channel complex(GO:0034707)
0.9 2.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.3 2.2 GO:0005833 hemoglobin complex(GO:0005833)
0.3 1.4 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.1 1.0 GO:0001939 female pronucleus(GO:0001939)
0.0 1.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.8 GO:0035976 AP1 complex(GO:0035976)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.8 GO:0030118 clathrin coat(GO:0030118)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 0.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.8 GO:0035240 dopamine binding(GO:0035240)
0.7 2.6 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.5 2.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 1.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)
0.3 0.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 0.9 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 0.8 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_FOXO_PATHWAY FoxO family signaling
0.1 0.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation