Motif ID: Srf

Z-value: 1.487


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.503.6e-02Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 11.526 ENSMUST00000165033.1
 Egr1
early growth response 1
chr7_-_19310035 4.058 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr13_+_51846673 3.889 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr10_-_120899067 3.615 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr12_+_85473883 2.838 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr6_-_23248264 2.820 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_+_79988584 2.246 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr7_-_137314394 1.779 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr7_-_44997535 1.720 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr10_-_111997204 1.694 ENSMUST00000074805.5
 Glipr1
GLI pathogenesis-related 1 (glioma)
chr14_-_5389049 1.667 ENSMUST00000177986.1
 Gm3500
predicted gene 3500
chr16_-_24393588 1.661 ENSMUST00000181640.1
 1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr14_+_3049285 1.557 ENSMUST00000166494.1
 Gm2897
predicted gene 2897
chr7_+_101896340 1.538 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr14_-_6287250 1.505 ENSMUST00000170104.2
 Gm3411
predicted gene 3411
chr14_-_7568566 1.461 ENSMUST00000163790.1
 Gm3558
predicted gene 3558
chr7_-_142661305 1.348 ENSMUST00000105936.1
 Igf2
insulin-like growth factor 2
chr7_+_44997648 1.322 ENSMUST00000003284.8
ENSMUST00000107835.1
 Irf3

interferon regulatory factor 3

chr8_-_71381907 1.314 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr14_-_5880382 1.309 ENSMUST00000164484.1
 Gm8237
predicted gene 8237

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 11.5 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 4.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.4 3.9 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.9 3.6 GO:0030091 protein repair(GO:0030091)
0.5 2.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 2.8 GO:0035994 response to muscle stretch(GO:0035994)
0.3 2.7 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.2 2.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 2.2 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.4 1.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.2 1.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.4 GO:0045214 sarcomere organization(GO:0045214)
0.3 1.3 GO:0050689 negative regulation of interferon-beta biosynthetic process(GO:0045358) negative regulation of defense response to virus by host(GO:0050689)
0.1 1.3 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.4 1.2 GO:2000836 positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845)
0.2 1.2 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 1.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 1.1 GO:0001706 endoderm formation(GO:0001706)
0.2 1.0 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.8 GO:0035976 AP1 complex(GO:0035976)
0.1 2.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.5 GO:0000124 SAGA complex(GO:0000124)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.2 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0016460 myosin II complex(GO:0016460)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 11.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 7.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 3.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 2.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.7 GO:0002039 p53 binding(GO:0002039)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.4 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.2 1.2 GO:0002135 CTP binding(GO:0002135)
0.1 1.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 1.0 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.3 0.8 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 3.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 2.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects