Motif ID: Hoxa6

Z-value: 0.763


Transcription factors associated with Hoxa6:

Gene SymbolEntrez IDGene Name
Hoxa6 ENSMUSG00000043219.8 Hoxa6



Activity profile for motif Hoxa6.

activity profile for motif Hoxa6


Sorted Z-values histogram for motif Hoxa6

Sorted Z-values for motif Hoxa6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_15185203 3.662 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr1_-_163313661 3.121 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr13_-_103764502 2.476 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr5_-_123141067 2.253 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr14_-_48665098 2.167 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_6730051 1.623 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr19_+_55894508 1.622 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr10_-_45470201 1.505 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr10_-_92164666 1.443 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr13_-_83729544 1.436 ENSMUST00000181705.1
 Gm26803
predicted gene, 26803
chr14_-_122451109 1.431 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr7_-_37773555 1.334 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr1_+_137928100 1.323 ENSMUST00000054333.2
 A130050O07Rik
RIKEN cDNA A130050O07 gene
chr6_+_15185456 1.321 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr4_+_11579647 1.308 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr4_-_110292719 1.292 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_42067960 1.272 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr13_-_40730416 1.218 ENSMUST00000021787.5
 Tfap2a
transcription factor AP-2, alpha
chr2_+_70474923 1.210 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chrM_+_7005 1.204 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.9 3.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 3.2 GO:0048664 neuron fate determination(GO:0048664)
0.2 2.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 2.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 1.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 1.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.5 1.6 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) negative regulation of immature T cell proliferation in thymus(GO:0033088) cloaca development(GO:0035844) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) metanephric S-shaped body morphogenesis(GO:0072284) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.2 1.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 1.2 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.0 1.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) negative regulation of keratinocyte differentiation(GO:0045617) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 1.0 GO:0060539 diaphragm development(GO:0060539)
0.0 1.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 1.0 GO:0035855 megakaryocyte development(GO:0035855)
0.3 0.9 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.9 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.2 GO:0000792 heterochromatin(GO:0000792)
0.0 2.2 GO:0032993 protein-DNA complex(GO:0032993)
0.2 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.2 GO:0008623 CHRAC(GO:0008623)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.4 GO:0044299 C-fiber(GO:0044299)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.0 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 2.5 GO:0001047 core promoter binding(GO:0001047)
0.1 2.1 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.9 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.6 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 0.8 GO:0016015 morphogen activity(GO:0016015)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0042054 histone methyltransferase activity(GO:0042054)
0.2 0.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines