Motif ID: Ddit3

Z-value: 0.889


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_1272908030.465.4e-02Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_109823585 4.428 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr19_-_59076069 3.560 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_-_66948419 3.101 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr9_-_121495678 2.766 ENSMUST00000035120.4
 Cck
cholecystokinin
chr10_+_112271123 2.684 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr3_+_9403049 2.300 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr3_-_127409014 2.023 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
 Ank2


ankyrin 2, brain


chr15_-_43869993 1.991 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chrX_+_103422010 1.844 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_4334001 1.772 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr3_-_127408937 1.628 ENSMUST00000183095.1
ENSMUST00000182610.1
 Ank2

ankyrin 2, brain

chr6_+_86078070 1.515 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr6_+_21215472 1.484 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr5_+_137553517 1.471 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr5_+_137288273 1.442 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr3_-_53657339 1.424 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr17_-_46890405 1.346 ENSMUST00000086675.3
 A330017A19Rik
RIKEN cDNA A330017A19 gene
chr5_+_3343893 1.295 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr7_+_24112314 1.283 ENSMUST00000120006.1
ENSMUST00000005413.3
 Zfp112

zinc finger protein 112

chrX_-_162565514 1.279 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 3.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.3 2.8 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.7 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4 2.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 1.8 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.2 1.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.6 GO:0045475 locomotor rhythm(GO:0045475)
0.0 1.6 GO:0007416 synapse assembly(GO:0007416)
0.1 1.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 1.4 GO:0019695 choline metabolic process(GO:0019695)
0.2 1.3 GO:0044838 cell quiescence(GO:0044838)
0.0 1.3 GO:0051592 response to calcium ion(GO:0051592)
0.4 1.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 1.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 1.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 GO:0031430 M band(GO:0031430)
0.1 4.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 2.8 GO:0043203 axon hillock(GO:0043203)
0.2 2.6 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 2.5 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.2 1.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.0 1.0 GO:0005912 adherens junction(GO:0005912)
0.0 0.9 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.5 GO:0043196 varicosity(GO:0043196)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.4 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 GO:0030507 spectrin binding(GO:0030507)
0.0 5.8 GO:0005509 calcium ion binding(GO:0005509)
0.1 3.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 2.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.6 GO:0051787 misfolded protein binding(GO:0051787)
0.3 1.8 GO:0045322 unmethylated CpG binding(GO:0045322)
0.4 1.7 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 1.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.4 1.4 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.4 1.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.8 GO:0051018 protein kinase A binding(GO:0051018)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis