Motif ID: Elf1_Elf2_Etv2_Elf4

Z-value: 2.931

Transcription factors associated with Elf1_Elf2_Etv2_Elf4:

Gene SymbolEntrez IDGene Name
Elf1 ENSMUSG00000036461.9 Elf1
Elf2 ENSMUSG00000037174.12 Elf2
Elf4 ENSMUSG00000031103.6 Elf4
Etv2 ENSMUSG00000006311.8 Etv2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf2mm10_v2_chr3_-_51340555_51340584-0.718.9e-04Click!
Elf1mm10_v2_chr14_+_79481164_79481194-0.607.9e-03Click!
Elf4mm10_v2_chrX_-_48454152_484541930.175.1e-01Click!


Activity profile for motif Elf1_Elf2_Etv2_Elf4.

activity profile for motif Elf1_Elf2_Etv2_Elf4


Sorted Z-values histogram for motif Elf1_Elf2_Etv2_Elf4

Sorted Z-values for motif Elf1_Elf2_Etv2_Elf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf1_Elf2_Etv2_Elf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_84839833 8.516 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr4_+_124850679 7.416 ENSMUST00000102628.4
 Yrdc
yrdC domain containing (E.coli)
chr6_-_23248264 7.309 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_94653964 5.991 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr3_-_89418287 5.884 ENSMUST00000029679.3
 Cks1b
CDC28 protein kinase 1b
chr6_-_72390659 5.848 ENSMUST00000059983.9
 Vamp8
vesicle-associated membrane protein 8
chr2_+_5845243 5.637 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr4_-_45320580 5.456 ENSMUST00000030003.3
 Exosc3
exosome component 3
chr2_+_156840077 5.454 ENSMUST00000081335.6
ENSMUST00000073352.3
 Tgif2

TGFB-induced factor homeobox 2

chr19_+_25610533 5.403 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_-_126792469 5.216 ENSMUST00000032936.6
 Ppp4c
protein phosphatase 4, catalytic subunit
chr1_-_180330550 5.038 ENSMUST00000050581.3
 Gm5069
predicted pseudogene 5069
chr16_-_18811972 4.964 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45

chr16_-_22161450 4.961 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr13_-_98316967 4.897 ENSMUST00000022163.8
ENSMUST00000152704.1
 Btf3

basic transcription factor 3

chr11_-_69921057 4.867 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr5_+_140331860 4.689 ENSMUST00000071881.3
ENSMUST00000050205.5
ENSMUST00000110827.1
 Nudt1


nudix (nucleoside diphosphate linked moiety X)-type motif 1


chr19_+_8920358 4.682 ENSMUST00000096243.5
 B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr5_-_30907692 4.649 ENSMUST00000132034.2
ENSMUST00000132253.2
 Ost4

oligosaccharyltransferase 4 homolog (S. cerevisiae)

chr2_-_130179310 4.610 ENSMUST00000103199.4
 Snrpb
small nuclear ribonucleoprotein B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,026 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 69.0 GO:0008380 RNA splicing(GO:0008380)
0.6 40.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.9 31.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.4 28.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 27.7 GO:0006412 translation(GO:0006412)
0.3 27.1 GO:0006413 translational initiation(GO:0006413)
0.8 21.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.3 19.1 GO:0032543 mitochondrial translation(GO:0032543)
3.6 14.3 GO:0019323 pentose catabolic process(GO:0019323)
0.5 13.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 13.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.3 13.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 12.8 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 12.2 GO:0006270 DNA replication initiation(GO:0006270)
0.7 11.8 GO:0043248 proteasome assembly(GO:0043248)
0.7 11.7 GO:0000338 protein deneddylation(GO:0000338)
0.5 11.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.6 10.9 GO:0045116 protein neddylation(GO:0045116)
1.5 10.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.3 10.4 GO:0033119 negative regulation of RNA splicing(GO:0033119)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 393 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 70.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.1 56.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 33.2 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 30.3 GO:0016607 nuclear speck(GO:0016607)
0.1 29.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 27.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.8 22.1 GO:0005687 U4 snRNP(GO:0005687)
0.0 21.0 GO:0005615 extracellular space(GO:0005615)
0.4 20.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 17.2 GO:0008180 COP9 signalosome(GO:0008180)
0.2 16.3 GO:0005681 spliceosomal complex(GO:0005681)
1.5 13.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.4 13.4 GO:0044391 ribosomal subunit(GO:0044391)
0.0 13.4 GO:0005730 nucleolus(GO:0005730)
1.3 13.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.5 13.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 11.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 11.6 GO:0032040 small-subunit processome(GO:0032040)
0.5 11.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 11.0 GO:0005839 proteasome core complex(GO:0005839)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 612 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 134.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 36.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 21.2 GO:0017025 TBP-class protein binding(GO:0017025)
2.0 18.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.4 16.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.1 14.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 13.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 13.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 13.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 12.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.3 12.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.7 11.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 11.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.0 10.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 10.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 10.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 10.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
3.4 10.1 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.4 10.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.5 10.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 29.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 24.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 18.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 16.0 PID_ATR_PATHWAY ATR signaling pathway
0.4 13.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 12.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.3 10.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 10.4 PID_MYC_PATHWAY C-MYC pathway
0.1 10.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 9.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 9.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 8.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.3 8.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 8.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 7.9 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 6.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 5.8 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 67.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
1.2 65.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6 43.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 38.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.7 36.7 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4 20.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.6 18.7 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.1 17.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.4 17.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.6 12.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.5 12.5 REACTOME_KINESINS Genes involved in Kinesins
0.2 12.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 11.0 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.3 10.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.3 10.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5 10.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 9.8 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3 9.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 9.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.4 9.5 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation