Motif ID: Smad3
Z-value: 0.795
Transcription factors associated with Smad3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Smad3 | ENSMUSG00000032402.6 | Smad3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad3 | mm10_v2_chr9_-_63757933_63757994 | 0.48 | 4.5e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
| 0.6 | 10.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.4 | 1.2 | GO:0002314 | germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) xanthine metabolic process(GO:0046110) purine deoxyribonucleoside metabolic process(GO:0046122) regulation of adenosine receptor signaling pathway(GO:0060167) |
| 0.3 | 1.0 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.2 | 1.0 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
| 0.2 | 1.3 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.2 | 0.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.6 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.1 | 0.4 | GO:1904347 | intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770) |
| 0.1 | 1.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.3 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.1 | 1.8 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 0.7 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 0.5 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.1 | 8.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 0.2 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.0 | 0.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.5 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
| 0.0 | 0.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 2.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 1.0 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.0 | 0.6 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.0 | 0.6 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.0 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.0 | 0.4 | GO:0051894 | integrin activation(GO:0033622) positive regulation of focal adhesion assembly(GO:0051894) |
| 0.0 | 0.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.0 | 0.1 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.0 | 1.3 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 7.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 1.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 1.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.2 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 0.5 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 2.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.3 | 1.0 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 1.2 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 4.2 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.1 | 1.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.3 | GO:0001179 | RNA polymerase I transcription factor binding(GO:0001179) |
| 0.1 | 0.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 10.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 1.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 0.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.1 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.0 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.4 | PID_AURORA_A_PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.3 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.0 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 4.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 1.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
