Motif ID: Smad3

Z-value: 0.795


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_637579940.484.5e-02Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_53707532 4.151 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr13_-_21832194 2.249 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr13_+_23533869 2.098 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_+_23531044 1.926 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_21750505 1.867 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr18_-_77047243 1.828 ENSMUST00000137354.1
ENSMUST00000137498.1
 Katnal2

katanin p60 subunit A-like 2

chr13_-_23551648 1.805 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr6_-_72235559 1.794 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr5_-_116422858 1.616 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr13_+_23581563 1.575 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_-_22042949 1.564 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr9_-_66514567 1.516 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr13_+_22043189 1.469 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr13_+_21735055 1.463 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_-_21833575 1.316 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr18_-_74207771 1.287 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr7_+_82867327 1.284 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr2_-_163750169 1.229 ENSMUST00000017841.3
 Ada
adenosine deaminase
chr18_-_77047282 1.221 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
 Katnal2



katanin p60 subunit A-like 2



chr13_-_23571151 1.208 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 8.7 GO:0006342 chromatin silencing(GO:0006342)
1.4 4.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 2.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.8 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 1.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 1.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.4 1.2 GO:0002314 germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) xanthine metabolic process(GO:0046110) purine deoxyribonucleoside metabolic process(GO:0046122) regulation of adenosine receptor signaling pathway(GO:0060167)
0.3 1.0 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 1.0 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.6 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.5 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.5 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.1 0.4 GO:1904347 intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 7.9 GO:0000786 nucleosome(GO:0000786)
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.2 1.6 GO:0072687 meiotic spindle(GO:0072687)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0042393 histone binding(GO:0042393)
0.1 4.2 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.4 3.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.1 1.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.3 1.0 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.3 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.4 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 4.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.0 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway