Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.386

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 2.307 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 2.112 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr6_-_124779686 1.328 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr6_-_23248264 1.131 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_143460989 0.739 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr5_+_140607334 0.660 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_+_29694204 0.660 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr13_-_102905740 0.629 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_8666236 0.613 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr13_-_102906046 0.611 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_9100681 0.607 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr3_+_94372794 0.559 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr9_-_100486788 0.522 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta
chr10_+_128337761 0.486 ENSMUST00000005826.7
 Cs
citrate synthase
chr14_-_52104015 0.476 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chrX_+_106015699 0.419 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb
chr5_+_138187485 0.370 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr17_-_34000257 0.369 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr4_-_119294520 0.364 ENSMUST00000079644.6
 Ybx1
Y box protein 1
chr4_-_140774196 0.363 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.1 1.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 1.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 0.5 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.1 0.5 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.4 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.1 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.3 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.1 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.3 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.5 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0034618 arginine binding(GO:0034618)
0.0 0.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.2 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease