Motif ID: Nr2e3

Z-value: 1.232


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

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Top targets:


Showing 1 to 20 of 169 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 7.952 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr18_-_35215008 7.685 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr10_-_109764840 4.634 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr2_+_65620829 4.522 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr6_-_13839916 4.341 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr4_-_138396438 4.331 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr3_+_54156039 3.688 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr1_+_19103022 3.527 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr12_+_88953399 3.430 ENSMUST00000057634.7
 Nrxn3
neurexin III
chr5_+_19227046 2.809 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_+_32938955 2.759 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chrX_-_143933089 2.628 ENSMUST00000087313.3
 Dcx
doublecortin
chr5_-_104021919 2.596 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr2_-_45112890 2.516 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr5_+_19907774 2.461 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_58424042 2.402 ENSMUST00000034868.7
 Clk1
CDC-like kinase 1
chr11_-_42182924 2.380 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr16_-_22439570 2.349 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr3_+_68468162 2.336 ENSMUST00000182532.1
 Schip1
schwannomin interacting protein 1
chr10_-_109010955 2.334 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.7 8.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.9 7.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 6.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.5 5.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.2 4.8 GO:0006710 androgen catabolic process(GO:0006710)
0.6 4.8 GO:0005513 detection of calcium ion(GO:0005513)
0.9 4.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 4.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 3.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 3.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 3.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.3 3.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 2.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 2.6 GO:0071420 cellular response to histamine(GO:0071420)
0.0 2.6 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.4 2.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 2.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.5 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 2.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 10.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.8 7.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 4.8 GO:0005811 lipid particle(GO:0005811)
0.0 4.7 GO:0005635 nuclear envelope(GO:0005635)
0.3 4.5 GO:0031045 dense core granule(GO:0031045)
0.1 3.7 GO:0034704 calcium channel complex(GO:0034704)
0.0 3.6 GO:0030426 growth cone(GO:0030426)
0.1 3.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.2 2.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.6 2.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 2.3 GO:0005638 lamin filament(GO:0005638)
0.0 2.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.4 1.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 1.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 8.6 GO:0042043 neurexin family protein binding(GO:0042043)
2.0 8.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.2 7.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 6.6 GO:0008017 microtubule binding(GO:0008017)
0.1 6.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 5.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.7 4.8 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
1.1 4.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 4.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.3 3.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 3.2 GO:0042805 actinin binding(GO:0042805)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 2.6 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 2.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 2.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 2.1 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 2.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.0 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 7.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 4.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 3.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 2.9 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 2.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 1.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.9 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis