Motif ID: Tfap2a

Z-value: 1.694


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40730416_407304290.097.2e-01Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 7.415 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_+_159737510 5.678 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_146585239 5.448 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr10_-_86498836 5.106 ENSMUST00000120638.1
 Syn3
synapsin III
chr5_+_117841839 4.807 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr17_+_69969073 4.772 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969387 4.638 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969217 4.572 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_100015817 4.232 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr8_+_70493156 4.070 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr11_-_116110211 3.897 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr10_+_81575306 3.831 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr13_-_110280103 3.530 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_+_91945703 3.472 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr5_+_75152274 3.446 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr18_-_38601268 3.374 ENSMUST00000025295.6
 Spry4
sprouty homolog 4 (Drosophila)
chr11_-_102897123 3.362 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr9_+_26733728 3.095 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr13_+_54949388 3.071 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr12_+_40446050 3.056 ENSMUST00000037488.6
 Dock4
dedicator of cytokinesis 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 14.0 GO:0070842 aggresome assembly(GO:0070842)
2.1 8.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 6.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.4 5.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.8 5.0 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.6 4.8 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 4.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.1 4.2 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.8 4.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
1.4 4.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.7 4.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.6 4.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 4.1 GO:0046834 lipid phosphorylation(GO:0046834)
0.8 4.0 GO:0060178 regulation of exocyst localization(GO:0060178)
0.3 4.0 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 4.0 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.4 3.8 GO:0046959 habituation(GO:0046959)
0.5 3.6 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
1.1 3.4 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 3.4 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 8.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 7.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 6.2 GO:0048786 presynaptic active zone(GO:0048786)
0.1 5.9 GO:0030175 filopodium(GO:0030175)
0.3 5.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.9 5.7 GO:0072534 perineuronal net(GO:0072534)
1.3 5.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 4.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 4.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.4 GO:0000139 Golgi membrane(GO:0000139)
1.4 4.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.9 3.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 3.0 GO:0032420 stereocilium(GO:0032420)
1.0 2.9 GO:0098855 HCN channel complex(GO:0098855)
0.6 2.8 GO:1990037 Lewy body core(GO:1990037)
0.2 2.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.8 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.4 GO:0045545 syndecan binding(GO:0045545)
0.0 8.1 GO:0017137 Rab GTPase binding(GO:0017137)
1.1 6.8 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 6.2 GO:0030695 GTPase regulator activity(GO:0030695)
0.5 5.7 GO:0046625 sphingolipid binding(GO:0046625)
0.4 5.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 5.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 5.0 GO:0008017 microtubule binding(GO:0008017)
1.6 4.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 4.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 4.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 4.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 4.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.7 4.1 GO:0097001 ceramide binding(GO:0097001)
0.6 4.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.9 3.6 GO:0031720 haptoglobin binding(GO:0031720)
0.4 3.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 3.5 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 6.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.4 ST_ADRENERGIC Adrenergic Pathway
0.1 3.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 3.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 3.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.9 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 2.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.3 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 2.1 PID_FOXO_PATHWAY FoxO family signaling
0.1 1.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.4 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 7.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 6.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 6.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 5.9 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 5.8 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 5.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 4.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.6 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 4.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 3.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 3.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 3.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.0 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 2.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 2.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation