Motif ID: Fli1

Z-value: 1.476


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_325416020.322.0e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_136868537 12.919 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr1_-_175491130 12.275 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr1_-_191318090 8.604 ENSMUST00000046770.9
 Nenf
neuron derived neurotrophic factor
chr11_+_32000452 5.498 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr7_-_140082489 5.069 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr11_+_32000496 4.423 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr15_+_84167804 4.234 ENSMUST00000045289.4
 Pnpla3
patatin-like phospholipase domain containing 3
chr4_+_43406435 4.063 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr8_+_23035116 3.492 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr17_+_79051906 3.455 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr5_+_117133567 3.290 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr2_+_65845767 2.550 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_16752203 2.453 ENSMUST00000102884.3
ENSMUST00000020329.6
 Egfr

epidermal growth factor receptor

chr8_+_23035099 2.395 ENSMUST00000117662.1
 Ank1
ankyrin 1, erythroid
chr6_-_77979515 2.371 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_+_65845833 2.322 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_57011945 2.303 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr13_+_118714678 2.291 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr11_+_57011798 2.222 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr6_-_77979652 2.206 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 12.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 12.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.8 8.6 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 5.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 5.3 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.5 5.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 4.6 GO:0051823 radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823)
0.1 4.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 4.1 GO:0019433 triglyceride catabolic process(GO:0019433)
1.2 3.5 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.2 3.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.5 3.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 2.5 GO:0070459 prolactin secretion(GO:0070459)
0.8 2.3 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 1.9 GO:0016198 axon choice point recognition(GO:0016198)
0.1 1.7 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.6 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 1.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.8 GO:0005768 endosome(GO:0005768)
0.2 12.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.6 12.3 GO:0044292 dendrite terminus(GO:0044292)
0.6 11.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.8 4.5 GO:0044308 axonal spine(GO:0044308)
0.1 4.1 GO:0005811 lipid particle(GO:0005811)
0.0 3.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.6 2.5 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.3 1.0 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.9 15.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 13.0 GO:0019003 GDP binding(GO:0019003)
0.1 7.2 GO:0008083 growth factor activity(GO:0008083)
0.9 6.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.7 5.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 5.2 GO:0030507 spectrin binding(GO:0030507)
0.0 4.7 GO:0051015 actin filament binding(GO:0051015)
0.0 4.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 3.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 3.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.8 2.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.6 2.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 1.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 2.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 0.9 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.3 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 11.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 4.2 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.5 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.2 2.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.1 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation