Motif ID: Zic2

Z-value: 0.605


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.087.5e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 0.861 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 0.839 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr5_-_148392810 0.803 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr3_-_153725062 0.686 ENSMUST00000064460.5
 St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr4_+_42240639 0.645 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr1_+_74661794 0.632 ENSMUST00000129890.1
 Ttll4
tubulin tyrosine ligase-like family, member 4
chr5_-_142895233 0.620 ENSMUST00000035985.7
 Fbxl18
F-box and leucine-rich repeat protein 18
chr4_+_42091207 0.573 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr15_-_8710409 0.559 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_105519388 0.550 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chr7_-_17056669 0.538 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr15_+_25773985 0.526 ENSMUST00000125667.1
 Myo10
myosin X
chr9_-_60522017 0.514 ENSMUST00000140824.1
 Thsd4
thrombospondin, type I, domain containing 4
chr7_+_117380937 0.487 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr14_-_31206666 0.482 ENSMUST00000165981.1
ENSMUST00000171735.1
 Nisch

nischarin

chr5_-_122002340 0.479 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr7_+_121707189 0.473 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chrX_-_143933089 0.468 ENSMUST00000087313.3
 Dcx
doublecortin
chr10_-_61452658 0.466 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr16_+_35983424 0.462 ENSMUST00000173555.1
 Kpna1
karyopherin (importin) alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.9 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 0.8 GO:0015809 arginine transport(GO:0015809)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.7 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.7 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.2 0.6 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.1 0.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.5 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 0.5 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.3 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.3 GO:0032127 dense core granule membrane(GO:0032127)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.1 GO:0005178 integrin binding(GO:0005178)
0.1 0.9 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.8 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.2 0.7 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 0.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex