Motif ID: Crx_Gsc

Z-value: 0.566

Transcription factors associated with Crx_Gsc:

Gene SymbolEntrez IDGene Name
Crx ENSMUSG00000041578.9 Crx
Gsc ENSMUSG00000021095.4 Gsc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Crxmm10_v2_chr7_-_15879844_158799680.361.5e-01Click!


Activity profile for motif Crx_Gsc.

activity profile for motif Crx_Gsc


Sorted Z-values histogram for motif Crx_Gsc

Sorted Z-values for motif Crx_Gsc



Network of associatons between targets according to the STRING database.



First level regulatory network of Crx_Gsc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 2.313 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr4_+_74013442 1.624 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr11_+_104231390 1.569 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr9_-_53975246 1.460 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr2_+_69722797 1.094 ENSMUST00000090858.3
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr1_-_154725920 0.981 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr7_+_44384803 0.971 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr1_+_85575676 0.943 ENSMUST00000178024.1
 G530012D18Rik
RIKEN cDNA G530012D1 gene
chr14_+_61138445 0.938 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chr8_-_54724317 0.914 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
 Wdr17


WD repeat domain 17


chr7_+_44384098 0.909 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chr14_+_65968483 0.892 ENSMUST00000022616.6
 Clu
clusterin
chr12_-_69357120 0.823 ENSMUST00000021368.8
 Nemf
nuclear export mediator factor
chr13_+_110395041 0.812 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr11_-_70459957 0.759 ENSMUST00000019064.2
 Cxcl16
chemokine (C-X-C motif) ligand 16
chr7_+_44384604 0.683 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr2_-_164404606 0.670 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr8_-_54724474 0.668 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr7_+_99535439 0.651 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr12_-_25096080 0.637 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 2.0 GO:0006413 translational initiation(GO:0006413)
0.2 1.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 1.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 1.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.1 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.2 1.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 1.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.9 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 0.8 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.8 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.7 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.6 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.6 GO:0042756 drinking behavior(GO:0042756)
0.0 0.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.1 GO:0031143 pseudopodium(GO:0031143)
0.1 1.0 GO:0097165 nuclear stress granule(GO:0097165)
0.1 0.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 1.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 1.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.0 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.9 GO:0070840 dynein complex binding(GO:0070840)
0.3 0.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.8 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.5 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 1.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins