Motif ID: Cxxc1

Z-value: 0.548


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.635.3e-03Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 51 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_89302545 2.210 ENSMUST00000061728.3
Nog
noggin
chr12_+_110279228 2.000 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr7_-_49636847 1.288 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr11_-_69921057 1.222 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
Eif5a


eukaryotic translation initiation factor 5A


chr17_-_14203695 0.926 ENSMUST00000053218.5
Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr11_-_69920892 0.899 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
Eif5a


eukaryotic translation initiation factor 5A


chr11_-_68386974 0.825 ENSMUST00000135141.1
Ntn1
netrin 1
chr8_+_92357787 0.767 ENSMUST00000034184.10
Irx5
Iroquois related homeobox 5 (Drosophila)
chr3_-_101307079 0.752 ENSMUST00000097146.2
Gm10355
predicted gene 10355
chr19_-_4439388 0.711 ENSMUST00000117462.1
ENSMUST00000048197.3
Rhod

ras homolog gene family, member D

chr3_-_8964037 0.695 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52

tumor protein D52

chr11_+_32205483 0.650 ENSMUST00000121182.1
Snrnp25
small nuclear ribonucleoprotein 25 (U11/U12)
chr5_-_4758216 0.646 ENSMUST00000054294.4
Fzd1
frizzled homolog 1 (Drosophila)
chr5_-_65391408 0.642 ENSMUST00000057885.6
Rpl9
ribosomal protein L9
chr5_-_65391380 0.600 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
Rpl9


ribosomal protein L9


chr10_+_128058974 0.588 ENSMUST00000084771.2
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_-_125389177 0.573 ENSMUST00000108707.2
Ubc
ubiquitin C
chr10_+_128058947 0.558 ENSMUST00000052798.7
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr19_+_38931008 0.555 ENSMUST00000145051.1
Hells
helicase, lymphoid specific
chr11_+_32205411 0.551 ENSMUST00000039601.3
ENSMUST00000149043.1
Snrnp25

small nuclear ribonucleoprotein 25 (U11/U12)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.6 2.2 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 2.0 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.1 1.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.3 0.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.9 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.1 0.8 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.2 0.6 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 0.4 GO:1990047 spindle matrix(GO:1990047)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 2.2 GO:0019955 cytokine binding(GO:0019955)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.3 1.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.9 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 2.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 0.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS