Motif ID: Hlf

Z-value: 0.725


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.744.1e-04Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_107511489 1.766 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.736 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr19_+_60144682 1.608 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr6_-_23248264 1.534 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_+_23531044 1.489 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr18_+_50030977 1.287 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr17_+_43801823 1.176 ENSMUST00000044895.5
 Rcan2
regulator of calcineurin 2
chr7_-_114636299 1.050 ENSMUST00000032906.4
ENSMUST00000032907.7
 Calca

calcitonin/calcitonin-related polypeptide, alpha

chr4_-_97584605 1.029 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 0.999 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr12_-_110978981 0.958 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9


chr14_+_50955992 0.957 ENSMUST00000095925.4
 Pnp2
purine-nucleoside phosphorylase 2
chr16_+_92292380 0.938 ENSMUST00000047383.3
 Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr1_+_10993452 0.935 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_74791516 0.866 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr9_-_100506844 0.824 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr14_+_50944499 0.807 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr7_+_67647405 0.799 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr7_-_42578588 0.792 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr3_+_87906321 0.789 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 1.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 1.3 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 1.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.3 1.0 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.2 0.9 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.9 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 0.8 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 0.8 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 0.8 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.1 0.7 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.7 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.7 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.6 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.5 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.8 GO:0098536 deuterosome(GO:0098536)
0.1 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.5 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.3 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 1.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 1.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 1.0 GO:0005179 hormone activity(GO:0005179)
0.2 0.9 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.1 0.8 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.5 GO:0004074 biliverdin reductase activity(GO:0004074)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 1.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines