ISMARA results: Klf8

Motif ID: Klf8

Z-value: 1.015

Transcription factors associated with Klf8:

Gene Symbol	Entrez ID	Gene Name
Klf8	ENSMUSG00000041649.7	Klf8

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Klf8	mm10_v2_chrX_+_153359613_153359613	-0.86	5.6e-06	Click!

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_70851189	5.757	ENSMUST00000059775.8	Tgif1	TGFB-induced factor homeobox 1
chr19_+_25610533	3.856	ENSMUST00000048935.4	Dmrt3	doublesex and mab-3 related transcription factor 3
chr7_-_127026479	3.855	ENSMUST00000032916.4	Maz	MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_-_72788952	3.808	ENSMUST00000114053.2	Tcf7l1	transcription factor 7 like 1 (T cell specific, HMG box)
chr3_+_87948666	3.285	ENSMUST00000005019.5	Crabp2	cellular retinoic acid binding protein II
chr4_+_46450892	2.230	ENSMUST00000102926.4	Anp32b	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_172550991	2.156	ENSMUST00000170744.1	Tfap2c	transcription factor AP-2, gamma
chr3_+_94377432	2.146	ENSMUST00000107292.1	Rorc	RAR-related orphan receptor gamma
chr4_-_97778042	2.133	ENSMUST00000146447.1	E130114P18Rik	RIKEN cDNA E130114P18 gene
chr9_-_8004585	1.966	ENSMUST00000086580.5 ENSMUST00000065353.6	Yap1	yes-associated protein 1
chr2_+_165595009	1.963	ENSMUST00000088132.6	Eya2	eyes absent 2 homolog (Drosophila)
chr7_-_30973464	1.933	ENSMUST00000001279.8	Lsr	lipolysis stimulated lipoprotein receptor
chr13_+_48261427	1.869	ENSMUST00000021810.1	Id4	inhibitor of DNA binding 4
chr3_+_94377505	1.775	ENSMUST00000098877.2	Rorc	RAR-related orphan receptor gamma
chr16_+_30599717	1.763	ENSMUST00000059078.3	Fam43a	family with sequence similarity 43, member A
chr7_-_144939823	1.635	ENSMUST00000093962.4	Ccnd1	cyclin D1
chr2_-_54085542	1.592	ENSMUST00000100089.2	Rprm	reprimo, TP53 dependent G2 arrest mediator candidate
chr7_+_4119525	1.514	ENSMUST00000119661.1 ENSMUST00000129423.1	Ttyh1	tweety homolog 1 (Drosophila)
chr10_+_4710119	1.513	ENSMUST00000105588.1 ENSMUST00000105589.1	Esr1	estrogen receptor 1 (alpha)
chr7_+_4119556	1.502	ENSMUST00000079415.5	Ttyh1	tweety homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 146 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7	4.2	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.6	3.9	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.5	3.9	GO:0072615	interleukin-17 secretion(GO:0072615)
0.4	3.9	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.3	3.8	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3	3.8	GO:0048385	regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.1	3.0	GO:1902476	chloride transmembrane transport(GO:1902476)
0.7	2.9	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	2.7	GO:0009299	mRNA transcription(GO:0009299)
0.7	2.2	GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1	2.2	GO:0043486	histone exchange(GO:0043486)
0.4	2.1	GO:0018002	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.7	2.0	GO:0036166	phenotypic switching(GO:0036166)
0.4	2.0	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.3	2.0	GO:0060242	contact inhibition(GO:0060242)
0.3	2.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.6	1.9	GO:1904274	tricellular tight junction assembly(GO:1904274)
0.1	1.9	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.2	1.6	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 57 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0005667	transcription factor complex(GO:0005667)
0.1	6.1	GO:0017053	transcriptional repressor complex(GO:0017053)
1.3	4.0	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
1.0	3.0	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4	2.7	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3	2.1	GO:0031415	NatA complex(GO:0031415)
0.7	2.0	GO:0071149	TEAD-2-YAP complex(GO:0071149)
0.1	2.0	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.3	1.9	GO:0061689	tricellular tight junction(GO:0061689)
0.2	1.5	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.2	1.5	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.4	1.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	1.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	1.3	GO:0070469	respiratory chain(GO:0070469)
0.1	1.2	GO:0000796	condensin complex(GO:0000796)
0.0	1.2	GO:0005844	polysome(GO:0005844)
0.1	1.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	1.1	GO:0005902	microvillus(GO:0005902)
0.3	1.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.1	1.0	GO:0042555	MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 87 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.4	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.3	7.1	GO:0070410	co-SMAD binding(GO:0070410)
0.1	7.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.0	3.9	GO:0008142	oxysterol binding(GO:0008142)
0.5	3.3	GO:0019841	retinol binding(GO:0019841)
0.0	3.2	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.8	3.0	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.1	2.9	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	2.4	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.4	2.1	GO:1990190	peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.3	2.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	2.0	GO:0042393	histone binding(GO:0042393)
0.1	1.9	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.1	1.6	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5	1.5	GO:0031798	type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2	1.5	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	1.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	1.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	1.3	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	1.3	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)

Gene overrepresentation in C2:CP category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.5	PID_SMAD2_3NUCLEAR_PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	7.1	PID_DELTA_NP63_PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	2.6	PID_HNF3B_PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.2	PID_AR_TF_PATHWAY	Regulation of Androgen receptor activity
0.1	2.1	PID_WNT_SIGNALING_PATHWAY	Wnt signaling network
0.1	2.0	PID_INTEGRIN5_PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.8	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.8	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.1	1.6	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	1.5	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.0	1.4	PID_TCR_CALCIUM_PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.4	PID_HES_HEY_PATHWAY	Notch-mediated HES/HEY network
0.0	1.2	PID_HNF3A_PATHWAY	FOXA1 transcription factor network
0.0	1.2	ST_GAQ_PATHWAY	G alpha q Pathway
0.0	1.2	PID_HDAC_CLASSI_PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.1	PID_P53_REGULATION_PATHWAY	p53 pathway
0.0	1.0	PID_GLYPICAN_1PATHWAY	Glypican 1 network
0.0	0.9	PID_E2F_PATHWAY	E2F transcription factor network
0.0	0.9	PID_RHOA_REG_PATHWAY	Regulation of RhoA activity
0.0	0.7	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 41 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.1	REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	4.0	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	3.9	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	3.2	REACTOME_NUCLEAR_SIGNALING_BY_ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	3.2	REACTOME_TRANSLATION	Genes involved in Translation
0.1	2.8	REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	2.4	REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.1	2.0	REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	2.0	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	1.8	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
0.0	1.5	REACTOME_GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	1.2	REACTOME_ACTIVATION_OF_RAC	Genes involved in Activation of Rac
0.0	1.1	REACTOME_COLLAGEN_FORMATION	Genes involved in Collagen formation
0.0	1.0	REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	1.0	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	0.9	REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	0.9	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.8	REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.8	REACTOME_KINESINS	Genes involved in Kinesins
0.0	0.7	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)