Motif ID: Glis2

Z-value: 1.096


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_4594735-0.381.2e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 8.137 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr2_-_54085542 4.248 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_-_58499398 3.474 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr4_+_109978004 3.015 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_-_48840988 2.848 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr5_+_136084022 2.714 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr5_+_136083916 2.676 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr19_+_55741810 2.561 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_+_4976113 2.419 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr17_+_80127447 2.306 ENSMUST00000039205.4
 Galm
galactose mutarotase
chr7_+_28881656 2.199 ENSMUST00000066880.4
 Capn12
calpain 12
chr5_+_115327125 2.170 ENSMUST00000031513.7
 Srsf9
serine/arginine-rich splicing factor 9
chr11_+_101468164 2.148 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr2_+_174330006 2.143 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
 Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr6_+_48841633 2.127 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr2_-_57124003 2.115 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr19_-_45742873 2.100 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr6_+_48841476 2.090 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_-_48841098 2.089 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr3_-_66981279 2.088 ENSMUST00000162098.2
 Shox2
short stature homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.7 10.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 5.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.9 3.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.9 3.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.1 3.3 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.3 3.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.3 3.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)
0.3 2.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 2.4 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.5 2.3 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 2.3 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 2.2 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.7 2.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.4 2.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 2.0 GO:0001675 acrosome assembly(GO:0001675)
0.6 1.9 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.1 GO:0016607 nuclear speck(GO:0016607)
0.0 3.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 2.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.9 GO:0005882 intermediate filament(GO:0005882)
0.3 2.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.3 GO:0016235 aggresome(GO:0016235)
0.3 2.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 2.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.3 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.3 GO:0009986 cell surface(GO:0009986)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.1 GO:0019841 retinol binding(GO:0019841)
0.5 3.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 3.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
1.1 3.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 2.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 2.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 2.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.6 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 2.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.3 2.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.2 GO:0005112 Notch binding(GO:0005112)
0.7 2.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 2.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 2.0 GO:0004540 ribonuclease activity(GO:0004540)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.4 1.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.1 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 3.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.2 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.3 2.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport