Motif ID: Tbr1

Z-value: 1.035


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_618045380.194.5e-01Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 6.591 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr2_+_164562579 3.618 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr10_+_26229707 3.583 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 2.651 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr14_-_70642268 2.618 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr1_-_138848576 2.508 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr9_-_43239816 2.314 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr17_+_29093763 2.184 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr17_+_87635974 2.047 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr9_+_3025417 2.027 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 1.889 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr1_+_12692430 1.847 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chrX_+_96455359 1.836 ENSMUST00000033553.7
 Heph
hephaestin
chr12_+_109459843 1.735 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr3_-_95904683 1.689 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr9_-_21760275 1.670 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_-_130573118 1.658 ENSMUST00000159694.1
 Nsmce4a
non-SMC element 4 homolog A (S. cerevisiae)
chr7_-_116237767 1.653 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr3_-_157925056 1.588 ENSMUST00000118539.1
 Cth
cystathionase (cystathionine gamma-lyase)
chr7_-_144939823 1.515 ENSMUST00000093962.4
 Ccnd1
cyclin D1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 291 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 6.6 GO:0030091 protein repair(GO:0030091)
1.0 5.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 3.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.9 2.8 GO:0030421 defecation(GO:0030421)
0.1 2.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.5 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.4 2.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.5 2.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.3 2.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.7 2.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.2 2.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.3 2.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 2.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 2.0 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.5 1.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 1.8 GO:0006825 copper ion transport(GO:0006825)
0.1 1.7 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.3 1.6 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
0.0 1.6 GO:0000266 mitochondrial fission(GO:0000266)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0005925 focal adhesion(GO:0005925)
0.0 3.7 GO:0030027 lamellipodium(GO:0030027)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.4 GO:0005915 zonula adherens(GO:0005915)
0.0 2.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 2.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.5 2.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 1.7 GO:0031262 Ndc80 complex(GO:0031262)
0.2 1.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 1.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 1.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.6 GO:0070652 HAUS complex(GO:0070652)
0.1 1.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 1.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.7 3.6 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 3.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 2.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.9 2.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 2.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 2.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 2.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 2.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 2.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 2.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 2.0 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 1.8 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 1.8 GO:0004065 arylsulfatase activity(GO:0004065)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 3.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 2.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.5 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 1.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 2.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 2.5 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 1.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 1.5 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.2 1.4 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.4 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.4 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC