Motif ID: Foxo3

Z-value: 0.967


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.736.4e-04Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 3.959 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr10_+_112271123 3.066 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr11_+_3332426 2.820 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr7_+_82175156 2.251 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr4_-_116405986 2.222 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chrX_+_159697308 2.199 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr6_+_55836878 2.160 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr14_-_121698417 2.093 ENSMUST00000040700.7
 Dock9
dedicator of cytokinesis 9
chr11_+_29463735 1.912 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr4_-_87806276 1.847 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_-_101785252 1.839 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr2_+_136713444 1.819 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr11_+_85353156 1.728 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr4_-_87806296 1.727 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr3_+_63295815 1.712 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr16_+_93683184 1.706 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr5_+_66968559 1.689 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr16_-_43979050 1.521 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr7_-_103813913 1.517 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr11_-_60352869 1.505 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
 Tom1l2





target of myb1-like 2 (chicken)






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 3.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4 3.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 3.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.4 2.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 2.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 2.2 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.4 1.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 1.9 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 1.8 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 1.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.6 1.7 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.7 GO:0042182 ketone catabolic process(GO:0042182)
0.1 1.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 1.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.1 1.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.1 GO:0030673 axolemma(GO:0030673)
0.0 2.7 GO:0005769 early endosome(GO:0005769)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.9 GO:0036064 ciliary basal body(GO:0036064)
0.5 1.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.4 1.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.1 GO:0045179 apical cortex(GO:0045179)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.1 1.0 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.6 GO:0032300 mismatch repair complex(GO:0032300)
0.1 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.9 2.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 2.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.3 1.9 GO:0097001 ceramide binding(GO:0097001)
0.1 1.9 GO:0043422 protein kinase B binding(GO:0043422)
0.3 1.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.6 1.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.6 1.7 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 1.5 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.4 1.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 1.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.5 GO:0030276 clathrin binding(GO:0030276)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.1 GO:0004697 protein kinase C activity(GO:0004697) phospholipase binding(GO:0043274)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 1.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 1.4 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.2 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 0.7 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis