Motif ID: Gli2

Z-value: 0.547


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.401.0e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_72789240 2.244 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_72788952 2.193 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_23248264 1.634 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_24527276 1.322 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr7_-_4752972 1.237 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr7_-_137314394 0.983 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr9_-_43239816 0.969 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chrX_-_141725181 0.948 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr8_+_127064022 0.942 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr3_-_135608221 0.928 ENSMUST00000132668.1
 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr7_-_144738520 0.914 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel

chr4_+_124700700 0.874 ENSMUST00000106199.3
ENSMUST00000038684.5
 Fhl3

four and a half LIM domains 3

chr8_+_127063893 0.840 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr7_-_116308241 0.834 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr7_-_144738478 0.774 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr13_+_35741313 0.682 ENSMUST00000163595.2
 Cdyl
chromodomain protein, Y chromosome-like
chr8_+_127064107 0.638 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr9_+_62342449 0.615 ENSMUST00000156461.1
 Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_121039385 0.606 ENSMUST00000030372.5
 Col9a2
collagen, type IX, alpha 2
chr6_+_120666388 0.520 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.4 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.4 2.4 GO:0003383 apical constriction(GO:0003383)
0.3 1.7 GO:0015705 iodide transport(GO:0015705)
0.3 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 1.3 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.8 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.8 GO:0040031 snRNA modification(GO:0040031)
0.1 0.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.7 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.1 0.5 GO:0001842 neural fold formation(GO:0001842)
0.0 0.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.5 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.4 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.1 0.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.4 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0033269 internode region of axon(GO:0033269)
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.1 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.5 GO:0090537 CERF complex(GO:0090537)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.4 GO:0089701 U2AF(GO:0089701)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.3 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0008013 beta-catenin binding(GO:0008013)
0.1 2.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 1.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 1.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.9 GO:0042805 actinin binding(GO:0042805)
0.0 0.9 GO:0005158 insulin receptor binding(GO:0005158)
0.2 0.8 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.6 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.4 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.3 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.3 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation