Motif ID: Zbtb7a

Z-value: 0.631


Transcription factors associated with Zbtb7a:

Gene SymbolEntrez IDGene Name
Zbtb7a ENSMUSG00000035011.9 Zbtb7a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7amm10_v2_chr10_+_81137953_811379920.663.1e-03Click!


Activity profile for motif Zbtb7a.

activity profile for motif Zbtb7a


Sorted Z-values histogram for motif Zbtb7a

Sorted Z-values for motif Zbtb7a



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_44234014 1.994 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr8_-_11008458 1.841 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr7_+_96210107 1.534 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr7_+_49246812 1.451 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr18_+_32938955 1.410 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr16_+_11984581 1.369 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr11_-_107915041 1.347 ENSMUST00000039071.2
 Cacng5
calcium channel, voltage-dependent, gamma subunit 5
chr8_-_34965631 1.313 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr5_+_37028329 1.283 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr11_+_24076529 1.213 ENSMUST00000148087.1
 Gm12063
predicted gene 12063
chr9_+_100643755 1.211 ENSMUST00000133388.1
 Stag1
stromal antigen 1
chr4_-_123664725 1.189 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr15_-_100599864 1.164 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr2_+_180499893 1.095 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr15_-_98567630 1.047 ENSMUST00000012104.6
 Ccnt1
cyclin T1
chr5_-_139129662 1.044 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr1_+_86045863 1.039 ENSMUST00000165824.1
 2810459M11Rik
RIKEN cDNA 2810459M11 gene
chr11_+_75532127 0.972 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr17_-_17624458 0.954 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase
chr6_+_54681687 0.948 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 2.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 2.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.2 GO:0015807 L-amino acid transport(GO:0015807)
0.3 1.8 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.3 1.8 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.2 1.8 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 1.6 GO:0046856 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.5 1.5 GO:0070650 actin filament bundle distribution(GO:0070650)
0.4 1.5 GO:0060912 cardiac cell fate specification(GO:0060912)
0.4 1.5 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 1.5 GO:0070970 interleukin-2 secretion(GO:0070970)
0.1 1.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.4 1.3 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 1.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.3 1.2 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.2 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.2 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.1 1.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 2.0 GO:0016600 flotillin complex(GO:0016600)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.6 GO:0005903 brush border(GO:0005903)
0.3 1.5 GO:0097513 myosin II filament(GO:0097513)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 1.1 GO:0032280 symmetric synapse(GO:0032280)
0.1 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.3 1.0 GO:0044307 dendritic branch(GO:0044307)
0.1 1.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 0.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.9 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.8 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 1.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 1.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.1 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.1 GO:0097110 scaffold protein binding(GO:0097110)
0.2 1.0 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_EPO_PATHWAY EPO signaling pathway
0.1 3.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.3 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_INSULIN_PATHWAY Insulin Pathway
0.1 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.9 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 2.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 0.7 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 0.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling