Motif ID: Maz_Zfp281

Z-value: 1.394

Transcription factors associated with Maz_Zfp281:

Gene SymbolEntrez IDGene Name
Maz ENSMUSG00000030678.6 Maz
Zfp281 ENSMUSG00000041483.8 Zfp281

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mazmm10_v2_chr7_-_127026479_1270264960.663.2e-03Click!
Zfp281mm10_v2_chr1_+_136624901_136624949-0.029.4e-01Click!


Activity profile for motif Maz_Zfp281.

activity profile for motif Maz_Zfp281


Sorted Z-values histogram for motif Maz_Zfp281

Sorted Z-values for motif Maz_Zfp281



Network of associatons between targets according to the STRING database.



First level regulatory network of Maz_Zfp281

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 4.087 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr1_-_138847579 3.942 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr10_-_120476469 3.208 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr7_-_127026479 3.075 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_-_72390659 3.060 ENSMUST00000059983.9
 Vamp8
vesicle-associated membrane protein 8
chr8_-_87959560 2.963 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chrX_-_106485214 2.755 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr2_+_164562579 2.615 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_+_19094594 2.537 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr3_+_87948666 2.454 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr10_+_108332173 2.376 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr7_-_4515959 2.365 ENSMUST00000163710.1
ENSMUST00000166268.1
ENSMUST00000071798.6
ENSMUST00000178163.1
ENSMUST00000108587.2
 Tnnt1




troponin T1, skeletal, slow




chr3_+_131110350 2.341 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_144939823 2.331 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr4_+_41135743 2.317 ENSMUST00000040008.3
 Ube2r2
ubiquitin-conjugating enzyme E2R 2
chr4_-_97778042 2.274 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_55532453 2.224 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr9_+_85842852 2.179 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr11_-_102579461 2.131 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chrX_-_106485367 2.121 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,065 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 6.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.5 6.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 6.1 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.9 5.5 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
1.7 5.0 GO:0030421 defecation(GO:0030421)
0.1 4.3 GO:0006270 DNA replication initiation(GO:0006270)
0.8 4.2 GO:0048382 mesendoderm development(GO:0048382)
0.5 4.1 GO:0010587 miRNA catabolic process(GO:0010587)
1.3 4.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 3.8 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.4 3.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.1 3.4 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.2 3.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 3.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
1.1 3.3 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.7 3.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.3 3.2 GO:0072189 ureter development(GO:0072189)
1.0 3.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.0 3.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 380 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.9 GO:0005844 polysome(GO:0005844)
0.1 10.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 8.0 GO:0000791 euchromatin(GO:0000791)
0.0 5.9 GO:0000228 nuclear chromosome(GO:0000228)
0.0 5.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 5.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 4.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.0 GO:0005581 collagen trimer(GO:0005581)
0.0 4.0 GO:0005681 spliceosomal complex(GO:0005681)
0.3 3.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 3.6 GO:0097470 ribbon synapse(GO:0097470)
0.7 3.4 GO:0005861 troponin complex(GO:0005861)
0.5 3.4 GO:0001740 Barr body(GO:0001740)
0.3 3.4 GO:0043219 lateral loop(GO:0043219)
0.5 3.3 GO:0097452 GAIT complex(GO:0097452)
0.5 3.3 GO:0042627 chylomicron(GO:0042627)
0.2 3.2 GO:0045120 pronucleus(GO:0045120)
0.1 3.2 GO:0005685 U1 snRNP(GO:0005685)
0.0 3.1 GO:0022626 cytosolic ribosome(GO:0022626)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 568 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 12.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 11.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 8.7 GO:0070888 E-box binding(GO:0070888)
0.1 8.6 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.1 8.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 6.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 6.4 GO:0003680 AT DNA binding(GO:0003680)
0.3 6.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 6.2 GO:0008201 heparin binding(GO:0008201)
0.2 6.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 6.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.5 5.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 5.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.7 5.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 5.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.5 4.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 4.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.2 GO:0042393 histone binding(GO:0042393)
0.2 4.0 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 12.8 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 10.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 8.3 PID_BMP_PATHWAY BMP receptor signaling
0.5 6.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 6.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.4 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.4 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 10.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 10.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 10.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 9.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 8.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 6.0 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 5.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 5.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.5 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.2 4.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 4.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 4.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 3.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 3.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.3 3.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 3.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 3.0 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation